Methyl (2Z)-3-(4-methoxyphenyl)-2-propenoate

Base Information

• Chemical Name: Methyl (2Z)-3-(4-methoxyphenyl)-2-propenoate
• CAS No.: 19310-29-3
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2918990090
• Nikkaji Number: J1.472.492C
• Mol file: 19310-29-3.mol

Synonyms:19310-29-3;cis(Z)-p-Methoxymethylcinnamate;cis-Methyl p-methoxycinnamate;Methyl p-methoxycinnamate, cis;methyl (Z)-3-(4-methoxyphenyl)prop-2-enoate;3-(4-methoxy-phenyl)-acrylic acid methyl ester;Methyl (2Z)-3-(4-methoxyphenyl)-2-propenoate;methyl (z)-p-methoxycinnamate;(Z)-Methyl-p-methoxycinnamate;methyl (z)-4-methoxycinnamate;4-Methoxy-cis-cinnamic acid methyl ester;2-Propenoic acid, 3-(4-methoxyphenyl)-, methyl ester, cis;2-Propenoic acid, 3-(4-methoxyphenyl)-, methyl ester, (Z)-

Chemical Property of Methyl (2Z)-3-(4-methoxyphenyl)-2-propenoate

Chemical Property:

• PSA: 35.53000
• LogP: 1.88140
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=CC(=O)OC
• Isomeric SMILES: COC1=CC=C(C=C1)/C=C\C(=O)OC

Technology Process of Methyl (2Z)-3-(4-methoxyphenyl)-2-propenoate

There total 85 articles about Methyl (2Z)-3-(4-methoxyphenyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

para-iodoanisole (696-62-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl p-methoxycinnamate (832-01-9,3901-07-3,19310-29-3)

Guidance literature:

With hollow carbonnanonets supported palladium nanoparticles; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 1h; Time;

DOI:10.1039/c2cy20562a

Reference yield: 99.0%

methanol (67-56-1) + 3-(4'-methoxyphenyl)propenoic acid (830-09-1) → methyl p-methoxycinnamate (832-01-9,3901-07-3,19310-29-3)

Guidance literature:

3-(4'-methoxyphenyl)propenoic acid; With boron trichloride;

methanol;

DOI:10.1016/S0040-4039(01)00602-5

Reference yield: 98.0%

acetic acid methyl ester (79-20-9) + 4-methoxy-benzaldehyde (123-11-5) → methyl p-methoxycinnamate (832-01-9,3901-07-3,19310-29-3)

Guidance literature:

With titanium tetrachloride; di-n-propylamine; In toluene; at 0 - 20 ℃; for 5h;

upstream raw materials:

methanol

p-methoxycinnamoyl chloride

p-Coumaric Acid

methyl iodide

Downstream raw materials:

2,3-dibromo-3-(4-methoxyphenyl)propionic acid methyl ester

3-amino-3-(4-methoxyphenyl)propionic acid

p-methoxycinnamyl alcohol

methyl 3-(4-methoxyphenyl)propionate

Refernces

• 1、 Bailey, Gwendolyn A.,Fogg, Deryn E.. "Acrylate Metathesis via the Second-Generation Grubbs Catalyst: Unexpected Pathways Enabled by a PCy3-Generated Enolate". . p. 7318 - 7321. Retrieved 2015.
• 2、 Nesmelova,Sidyakin. "". . . Retrieved 1973.
• 3、 Cao, Jiafu,Li, Qiji,Liao, Xiu,Wang, Enhua,Wang, Li,Yang, Juan,Yang, Lishou,Yang, Qian,Yang, Xiaosheng,Yang, Yan. "Synthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells". supporting information. . Retrieved 2022/02/23.
• 4、 Hajipour, Abdol R.,Sadeghi, Shaghayegh. "Triazine-hyperbranched polymer-modified magnetic nanoparticles-supported nano-cobalt for C–C cross-coupling reactions". . p. 3219 - 3233. Retrieved 2021/08/06.