6-Methoxy-2-benzofurancarbaldehyde

Base Information

• Chemical Name: 6-Methoxy-2-benzofurancarbaldehyde
• CAS No.: 53860-74-5
• Molecular Formula: C10H8O3
• Molecular Weight: 176.17
• Hs Code.: 2932999099
• Mol file: 53860-74-5.mol

Synonyms:6-Methoxy-2-benzofurancarboxaldehyde;6-Methoxybenzofuran-2-carbaldehyde;6-Methoxy-1-benzofuran-2-carbaldehyde;

Chemical Property of 6-Methoxy-2-benzofurancarbaldehyde

Chemical Property:

• Vapor Pressure: 0.00147mmHg at 25°C
• Melting Point: 78-80 °C
• Refractive Index: 1.619
• Boiling Point: 296 °C at 760 mmHg
• Flash Point: 132.8 °C
• PSA: 39.44000
• Density: 1.24 g/cm³
• LogP: 2.25390

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxybenzofuran-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Methoxy-2-benzofurancarbaldehyde

There total 6 articles about 6-Methoxy-2-benzofurancarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 6-methoxybenzo[b]furan-2-carboxylate (50551-57-0) → 6-methoxy-1-benzofuran-2-carbaldehyde (53860-74-5)

Guidance literature:

ethyl 6-methoxybenzo[b]furan-2-carboxylate; With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 0.5h;

With manganese(IV) oxide; In 1,4-dioxane; for 3h; Reflux;

Reference yield: 61.0%

6-methoxybenzofuran (50551-63-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-methoxy-1-benzofuran-2-carbaldehyde (53860-74-5)

Guidance literature:

6-methoxybenzofuran; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 20 ℃; for 4h;

DOI:10.1039/b806918b

Reference yield: 27.0%

1-(2,2-diethoxyethoxy)-3-methoxybenzene (108639-46-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-methoxy-1-benzofuran-2-carbaldehyde (53860-74-5)

Guidance literature:

With trichlorophosphate; at 50 ℃; for 4h;

upstream raw materials:

1-(2,2-diethoxyethoxy)-3-methoxybenzene

N,N-dimethyl-formamide

2-Hydroxy-4-methoxybenzaldehyde

O-methylresorcine

Downstream raw materials:

3-(6-methoxy-1-benzofuran-2-yl)-2-(3-methoxyphenyl)prop-2-enenitrile

Refernces

• 1、 -. "S1P RECEPTORS MODULATORS". Page/Page column 67. . Retrieved 2010/04/30.
• 2、 Hirota, Takashi,Fujita, Hiroko,Sasaki, Kenji,Namba, Tetsuto. "A Novel Synthesis of Benzofuran and Related Compounds. III. The Vilsmeier Reaction of Phenoxyacetaldehyde Diethyl Acetals". . p. 1715 - 1716. Retrieved 2007/10/02.