OXY-PYRION? 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS

Base Information

• Chemical Name: OXY-PYRION? 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS
• CAS No.: 822-89-9
• Deprecated CAS: 119167-17-8
• Molecular Formula: C5H5NO2
• Molecular Weight: 111.1
• European Community (EC) Number: 236-100-8,212-506-0
• NSC Number: 406972
• UNII: YO3915897S
• DSSTox Substance ID: DTXSID70231622
• Nikkaji Number: J195.073H,J31.363G
• Wikidata: Q27294618
• ChEMBL ID: CHEMBL3898657,CHEMBL81398
• Mol file: 822-89-9.mol

Synonyms:2(1H)-Pyridone,1-hydroxy- (6CI,7CI,8CI);1-Hydroxy-2(1H)-pyridinone;1-Hydroxy-2(1H)-pyridone;1-Hydroxy-2-pyridinone;1-Hydroxy-2-pyridone;N-Hydroxy-2-pyridone;

Chemical Property of OXY-PYRION? 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS

Chemical Property:

• Vapor Pressure: 0.00304mmHg at 25°C
• Melting Point: 149-150 °C
• Refractive Index: 1.628
• Boiling Point: 252.3 °C at 760 mmHg
• PKA: 6.00±0.10(Predicted)
• Flash Point: 106.4 °C
• PSA: 42.23000
• Density: 1.431 g/cm³
• LogP: 0.08560
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 111.032028402
• Heavy Atom Count: 8
• Complexity: 160

Purity/Quality:

99.9% ^*data from raw suppliers

2-Pyridinol 1-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=O)N(C=C1)O

Technology Process of OXY-PYRION? 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS

There total 21 articles about OXY-PYRION? 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

methanol (67-56-1) + 1-(9-anthryl)methyloxy-2-pyridone (220196-57-6) → 2-Pyridone (142-08-5,1199357-22-6) + 1-Hydroxy-2-pyridon (822-89-9) + 9-(methoxymethyl)anthracene (2584-79-4)

Guidance literature:

In methanol; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(98)02282-5

Reference yield: 19.4%

1-(pyren-1-ylmethyloxy)-2-pyridone (220196-58-7) → 2-Pyridone (142-08-5,1199357-22-6) + 1-Hydroxy-2-pyridon (822-89-9) + 1-pyrenemethanol (24463-15-8) + methyl 1-pyrenylmethyl ether (91385-15-8)

Guidance literature:

In methanol; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(98)02282-5

Reference yield: 5.0%

1-(pyren-1-ylmethyloxy)-2-pyridone (220196-58-7) → 2-Pyridone (142-08-5,1199357-22-6) + 1-Hydroxy-2-pyridon (822-89-9) + pyrene-1-aldehyde (3029-19-4) + methyl 1-pyrenylmethyl ether (91385-15-8)

Guidance literature:

In methanol; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(98)02282-5

upstream raw materials:

2-Pyridone

2-ethoxylpyridine N-oxide

1-(benzyloxy)pyridin-2(1H)-one

2-benzyloxypyridine 1-oxide

Downstream raw materials:

(+/-)-1-((1-benzyl-6-oxopiperidin-3-yl)methoxy)pyridin-2(1H)-one

1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one

1-(2,4-dinitrophenoxy)pyridin-2(1H)-one

cipemastat

Refernces

• 1、 Major Jourden, Jody L.,Cohen, Seth M.. "Hydrogen peroxide activated matrix metalloproteinase inhibitors: A prodrug approach". supporting information; experimental part. p. 6795 - 6797. Retrieved 2010/12/19.
• 2、 Yoshioka, Nariyoshi,Andoh, Chihei,Kubo, Kanji,Igarashi, Tetsutaro,Sakurai, Tadamitsu. "Competitive occurrence of homolytic N-O and heterolytic C-O bond cleavage in excited-state 1-(arylmethyloxy)-2-pyridones". . p. 1927 - 1932. Retrieved 2007/10/03.