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(R)-(-)-Rolipram

Base Information Edit
  • Chemical Name:(R)-(-)-Rolipram
  • CAS No.:85416-75-7
  • Molecular Formula:C16H21NO3
  • Molecular Weight:275.348
  • Hs Code.:2933790090
  • UNII:DPX51KUP08
  • DSSTox Substance ID:DTXSID101318033
  • Nikkaji Number:J534.336D
  • Wikidata:Q27094987
  • Pharos Ligand ID:JYQ5VTU36DSX
  • Metabolomics Workbench ID:52242
  • ChEMBL ID:CHEMBL430893
  • Mol file:85416-75-7.mol
(R)-(-)-Rolipram

Synonyms:(R)-(-)-Rolipram;85416-75-7;(R)-ROLIPRAM;(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one;(-)-ROLIPRAM;(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE;R-Rolipram;Rolipram, (R)-;Rolipram, (-)-;(4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one;UNII-DPX51KUP08;DPX51KUP08;CHEMBL430893;CHEBI:40133;(R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one;2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)-;2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-;2-PYRROLIDINONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)-, (4R)-;1xmy;NCGC00016899-01;CAS-61413-54-5;Tocris-0905;Tocris-1349;Tocris-1350;1q9m;1ro6;3g4k;Lopac-R-6520;D01RUN;SCHEMBL576805;DTXSID101318033;HMS3267P19;HMS3412I06;HMS3676I06;BCP14111;BDBM50042058;HB2898;HY-16900A;MFCD03093860;AKOS015891287;CCG-208064;CS-3246;DB04149;NCGC00015898-01;NCGC00015898-02;NCGC00015898-10;NCGC00016899-02;NCGC00016899-03;NCGC00016899-04;NCGC00016899-05;NCGC00024862-01;NCGC00024862-02;NCGC00024862-03;AC-22384;AS-31755;R0182;A863588;AE-641/11320426;SR-01000597573;SR-01000597573-1;BRD-K75516118-001-01-7;Q27094987;4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one;(4R)-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE;(R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one;(4R)-4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)-2-PYRROLIDINONE

Suppliers and Price of (R)-(-)-Rolipram
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • R-(-)-Rolipram
  • 5mg
  • $ 140.00
  • Tocris
  • (R)-(-)-Rolipram ≥98%(HPLC)
  • 50
  • $ 876.00
  • Tocris
  • (R)-(-)-Rolipram ≥98%(HPLC)
  • 10
  • $ 212.00
  • TCI Chemical
  • (R)-(-)-Rolipram >98.0%(HPLC)
  • 10mg
  • $ 162.00
  • TCI Chemical
  • (R)-(-)-Rolipram >98.0%(HPLC)
  • 50mg
  • $ 564.00
  • DC Chemicals
  • (R)-(-)-Rolipram >98%
  • 250 mg
  • $ 800.00
  • DC Chemicals
  • (R)-(-)-Rolipram >98%
  • 100 mg
  • $ 400.00
  • Crysdot
  • (R)-(-)-Rolipram 98+%
  • 50mg
  • $ 358.00
  • ChemScene
  • (R)-(-)-Rolipram 99.91%
  • 50mg
  • $ 390.00
  • ChemScene
  • (R)-(-)-Rolipram 99.91%
  • 10mg
  • $ 110.00
Total 29 raw suppliers
Chemical Property of (R)-(-)-Rolipram Edit
Chemical Property:
  • Melting Point:132.0 to 136.0 °C 
  • Boiling Point:472.7 °C at 760 mmHg 
  • PKA:16.02±0.40(Predicted) 
  • Flash Point:239.7 °C 
  • PSA:47.56000 
  • Density:1.155 g/cm3 
  • LogP:2.94890 
  • Storage Temp.:Store at RT 
  • Solubility.:DMSO (Slightly), Methanol (Slightly) 
  • XLogP3:2.2
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:4
  • Exact Mass:275.15214353
  • Heavy Atom Count:20
  • Complexity:341
Purity/Quality:

97% *data from raw suppliers

R-(-)-Rolipram *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
  • Isomeric SMILES:COC1=C(C=C(C=C1)[C@H]2CC(=O)NC2)OC3CCCC3
  • Uses R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.
Technology Process of (R)-(-)-Rolipram

There total 106 articles about (R)-(-)-Rolipram which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol103054a
Guidance literature:
With bis(norbornadiene)rhodium(l)tetrafluoroborate; zhaophos; hydrogen; In dichloromethane; at 35 ℃; for 48h; under 45603.1 Torr; enantioselective reaction;
DOI:10.1021/acscatal.8b00827
Guidance literature:
With C33H32F6N4O3; In dichloromethane; at 20 ℃; for 24h; enantioselective reaction;
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