(R)-(-)-Rolipram

Base Information Edit

Chemical Name:(R)-(-)-Rolipram
CAS No.:85416-75-7
Molecular Formula:C16H21NO3
Molecular Weight:275.348
Hs Code.:2933790090
UNII:DPX51KUP08
DSSTox Substance ID:DTXSID101318033
Nikkaji Number:J534.336D
Wikidata:Q27094987
Pharos Ligand ID:JYQ5VTU36DSX
Metabolomics Workbench ID:52242
ChEMBL ID:CHEMBL430893
Mol file:85416-75-7.mol

Synonyms:(R)-(-)-Rolipram;85416-75-7;(R)-ROLIPRAM;(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one;(-)-ROLIPRAM;(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE;R-Rolipram;Rolipram, (R)-;Rolipram, (-)-;(4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one;UNII-DPX51KUP08;DPX51KUP08;CHEMBL430893;CHEBI:40133;(R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one;2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)-;2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-;2-PYRROLIDINONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)-, (4R)-;1xmy;NCGC00016899-01;CAS-61413-54-5;Tocris-0905;Tocris-1349;Tocris-1350;1q9m;1ro6;3g4k;Lopac-R-6520;D01RUN;SCHEMBL576805;DTXSID101318033;HMS3267P19;HMS3412I06;HMS3676I06;BCP14111;BDBM50042058;HB2898;HY-16900A;MFCD03093860;AKOS015891287;CCG-208064;CS-3246;DB04149;NCGC00015898-01;NCGC00015898-02;NCGC00015898-10;NCGC00016899-02;NCGC00016899-03;NCGC00016899-04;NCGC00016899-05;NCGC00024862-01;NCGC00024862-02;NCGC00024862-03;AC-22384;AS-31755;R0182;A863588;AE-641/11320426;SR-01000597573;SR-01000597573-1;BRD-K75516118-001-01-7;Q27094987;4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one;(4R)-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE;(R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one;(4R)-4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)-2-PYRROLIDINONE

Suppliers and Price of (R)-(-)-Rolipram

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
R-(-)-Rolipram
5mg
$ 140.00

Tocris
(R)-(-)-Rolipram ≥98%(HPLC)
50
$ 876.00

Tocris
(R)-(-)-Rolipram ≥98%(HPLC)
10
$ 212.00

TCI Chemical
(R)-(-)-Rolipram >98.0%(HPLC)
10mg
$ 162.00

TCI Chemical
(R)-(-)-Rolipram >98.0%(HPLC)
50mg
$ 564.00

DC Chemicals
(R)-(-)-Rolipram >98%
250 mg
$ 800.00

DC Chemicals
(R)-(-)-Rolipram >98%
100 mg
$ 400.00

Crysdot
(R)-(-)-Rolipram 98+%
50mg
$ 358.00

ChemScene
(R)-(-)-Rolipram 99.91%
50mg
$ 390.00

ChemScene
(R)-(-)-Rolipram 99.91%
10mg
$ 110.00

Total 29 raw suppliers

Chemical Property of (R)-(-)-Rolipram Edit

Chemical Property:

Melting Point:132.0 to 136.0 °C
Boiling Point:472.7 °C at 760 mmHg
PKA:16.02±0.40(Predicted)
Flash Point:239.7 °C
PSA：47.56000
Density:1.155 g/cm³
LogP:2.94890
Storage Temp.:Store at RT
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:275.15214353
Heavy Atom Count:20
Complexity:341

Purity/Quality:

97% ^*data from raw suppliers

R-(-)-Rolipram ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
Isomeric SMILES:COC1=C(C=C(C=C1)[C@H]2CC(=O)NC2)OC3CCCC3
Uses R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.

Technology Process of (R)-(-)-Rolipram

There total 106 articles about (R)-(-)-Rolipram which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (R)-tert-butyl 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate

: 85416-75-7
(R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol103054a

Reference yield: 98.0%

: 4-(3-cyclopentyloxy-4-methoxy-phenyl)-1,5-dihydro-pyrrol-2-one

: 85416-75-7
(R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: With bis(norbornadiene)rhodium(l)tetrafluoroborate; zhaophos; hydrogen; In dichloromethane; at 35 ℃; for 48h; under 45603.1 Torr; enantioselective reaction;
DOI:10.1021/acscatal.8b00827