6-Amino-2-methylbenzoxazole

Base Information

• Chemical Name: 6-Amino-2-methylbenzoxazole
• CAS No.: 5676-60-8
• Molecular Formula: C8H8 N2 O
• Molecular Weight: 148.164
• Hs Code.: 2934999090
• Mol file: 5676-60-8.mol

Synonyms:Benzoxazole,6-amino-2-methyl- (6CI,7CI,8CI); (2-Methylbenzoxazol-6-yl)amine;2-Methyl-1,3-benzoxazol-6-amine; 2-Methyl-6-aminobenzoxazole;2-Methylbenzoxazol-6-amine; 6-Amino-2-methylbenzoxazole

Chemical Property of 6-Amino-2-methylbenzoxazole

Chemical Property:

• Vapor Pressure: 0.00205mmHg at 25°C
• Melting Point: 144-146oC
• Boiling Point: 290.6°Cat760mmHg
• PKA: 2.71±0.10(Predicted)
• Flash Point: 129.6°C
• PSA: 52.05000
• Density: 1.254g/cm³
• LogP: 2.29960
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%, ^*data from raw suppliers

2-Methyl-1,3-benzoxazol-6-amine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Amino-2-methylbenzoxazole

There total 8 articles about 6-Amino-2-methylbenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-methyl-6-nitrobenzoxazole (5683-43-2) → 6-amino-2-methylbenzoxazole (5676-60-8)

Guidance literature:

With iron; ammonium chloride; In methanol; water; at 70 ℃; for 2h;

Reference yield:

tert-butyl(2-methyl-1,3-benzoxazol-6-yl)carbamate → 6-amino-2-methylbenzoxazole (5676-60-8)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 0 - 20 ℃; for 3h;

Reference yield:

2-methyl-6-nitrobenzoxazole (5683-43-2) + hexane (110-54-3) + iron (7439-89-6) → 6-amino-2-methylbenzoxazole (5676-60-8)

Guidance literature:

With sodium carbonate; In dichloromethane; water; acetic acid; ethyl acetate;

upstream raw materials:

2-methyl-6-nitrobenzoxazole

5-Nitro-2-aminophenol

2-methyl-1,3-benzoxazole

hexane

Downstream raw materials:

4-[N'-(2-Methyl-6-oxo-5,6-dihydro-3-oxa-1,5-diaza-s-indacen-7-ylidene)-hydrazino]-benzenesulfonamide

Refernces

• 1、 Balraju, Vadla,Jogula, Sridhar,Krishna, Vagolu Siva,Meda, Nikhila,Sriram, Dharmarajan. "Design, synthesis and biological evaluation of novel Pseudomonas aeruginosa DNA gyrase B inhibitors". . . Retrieved 2020/05/08.
• 2、 Zhang, Zhen,Li, Zongyang,Fu, Bin,Zhang, Zhenhua. "Palladium-catalyzed cross-coupling reaction of azides with isocyanides". supporting information. p. 16312 - 16315. Retrieved 2015/11/16.