Phenylacetic acid 3-(2-methylpiperidino)propyl ester

Base Information

• Chemical Name: Phenylacetic acid 3-(2-methylpiperidino)propyl ester
• CAS No.: 63906-46-7
• Molecular Formula: C₁₇H₂₅NO₂
• Molecular Weight: 275.391
• Hs Code.: 2933399090
• Mol file: 63906-46-7.mol

Synonyms:Aceticacid, phenyl-, ester with 2-methyl-1-piperidinepropanol (5CI)

Chemical Property of Phenylacetic acid 3-(2-methylpiperidino)propyl ester

Chemical Property:

• Vapor Pressure: 2.74E-06mmHg at 25°C
• Boiling Point: 390°C at 760 mmHg
• Flash Point: 124.9°C
• PSA: 29.54000
• Density: 1.024g/cm³
• LogP: 2.97470

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenylacetic acid 3-(2-methylpiperidino)propyl ester

There total 3 articles about Phenylacetic acid 3-(2-methylpiperidino)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methylpiperidin (109-05-7,3000-79-1) → phenyl-acetic acid-[3-(2-methyl-piperidino)-propyl ester] (63906-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 160 °C

2: benzene

With potassium carbonate; benzene;

DOI:10.1021/ja01216a051

Reference yield:

2-methylpiperidine-1-propanol (94-88-2) + phenylacetyl chloride (103-80-0) → phenyl-acetic acid-[3-(2-methyl-piperidino)-propyl ester] (63906-46-7)

Guidance literature:

With benzene;

DOI:10.1021/ja01216a051

Reference yield:

1-(3-chloro-propyl)-2-methyl-piperidine (66773-94-2) + phenylacetic acid (103-82-2) + isopropyl alcohol (67-63-0,8013-70-5) → phenyl-acetic acid-[3-(2-methyl-piperidino)-propyl ester] (63906-46-7)

Guidance literature:

upstream raw materials:

2-methylpiperidine-1-propanol

phenylacetyl chloride

1-(3-chloro-propyl)-2-methyl-piperidine

phenylacetic acid