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(9S)-9-Amino-9-deoxoerythromycin

Base Information Edit
  • Chemical Name:(9S)-9-Amino-9-deoxoerythromycin
  • CAS No.:26116-56-3
  • Molecular Formula:C37H70N2O12
  • Molecular Weight:734.969
  • Hs Code.:
  • European Community (EC) Number:406-790-7
  • UNII:YX9KV1OMA4
  • DSSTox Substance ID:DTXSID00180750
  • Nikkaji Number:J79.364G
  • Wikidata:Q27144058
  • Metabolomics Workbench ID:66614
  • ChEMBL ID:CHEMBL290242
  • Mol file:26116-56-3.mol
(9S)-9-Amino-9-deoxoerythromycin

Synonyms:9(s)-erythromycylamine;erythromyclamine;erythromyclamine, (9R)-isomer;erythromyclamine, (9S)-isomer

Suppliers and Price of (9S)-9-Amino-9-deoxoerythromycin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Erythromycylamine
  • 1mg
  • $ 531.00
  • Usbiological
  • Erythromycylamine
  • 1mg
  • $ 403.00
  • TRC
  • Erythromycylamine
  • 10mg
  • $ 1070.00
  • Medical Isotopes, Inc.
  • Erythromycylamine
  • 1 mg
  • $ 860.00
  • Cayman Chemical
  • Erythromycylamine
  • 5mg
  • $ 396.00
  • Cayman Chemical
  • Erythromycylamine
  • 1mg
  • $ 99.00
  • Cayman Chemical
  • Erythromycylamine
  • 10mg
  • $ 743.00
  • American Custom Chemicals Corporation
  • 9(S)-ERYTHROMYCYLAMINE 95.00%
  • 1MG
  • $ 704.55
  • American Custom Chemicals Corporation
  • 9(S)-ERYTHROMYCYLAMINE 95.00%
  • 10MG
  • $ 1593.90
  • AK Scientific
  • (9S)-9-Amino-9-deoxoerythromycin
  • 10mg
  • $ 1103.00
Total 32 raw suppliers
Chemical Property of (9S)-9-Amino-9-deoxoerythromycin Edit
Chemical Property:
  • Vapor Pressure:2.15E-30mmHg at 25°C 
  • Melting Point:123-127°C 
  • Refractive Index:1.539 
  • Boiling Point:810.3 °C at 760 mmHg 
  • PKA:13.41±0.70(Predicted) 
  • Flash Point:443.8 °C 
  • PSA:202.86000 
  • Density:1.19 g/cm3 
  • LogP:2.24410 
  • Storage Temp.:-20°C Freezer 
  • XLogP3:3.5
  • Hydrogen Bond Donor Count:6
  • Hydrogen Bond Acceptor Count:14
  • Rotatable Bond Count:7
  • Exact Mass:734.49287567
  • Heavy Atom Count:51
  • Complexity:1140
Purity/Quality:

99.9% *data from raw suppliers

Erythromycylamine *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi,Dangerous
  • Hazard Codes:Xi,N 
  • Statements: 41-50/53 
  • Safety Statements: 26-39-60-61 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CCC1C(C(C(C(C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)N)C)O)(C)O
  • Isomeric SMILES:CC[C@@H]1[C@@]([C@@H]([C@H]([C@H]([C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)N)C)O)(C)O
  • Uses (9S)-9-Amino-9-deoxoerythromycin is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. (9S)-9-Amino-9-deoxoerythromycin is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine. Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine. (9S)-9-Amino-9-deoxoerythromycin is a metabolite of Dirithromycin; an antibiotic
Technology Process of (9S)-9-Amino-9-deoxoerythromycin

There total 21 articles about (9S)-9-Amino-9-deoxoerythromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With methanol; sodium tetrahydroborate; at 20 ℃; for 8h; Reagent/catalyst; Temperature; Cooling with ice;
Guidance literature:
With methanol; sodium amalgam;
DOI:10.1021/ja00401a051
Guidance literature:
With titanium(III) chloride; sodium cyanoborohydride;
DOI:10.1016/S0040-4039(00)00417-2
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