2-chlorophenylhydroxylamine

Base Information

• Chemical Name: 2-chlorophenylhydroxylamine
• CAS No.: 10468-16-3
• Molecular Formula: C6H6 Cl N O
• Molecular Weight: 143.573
• Hs Code.: 2928000090
• Mol file: 10468-16-3.mol

Synonyms:Hydroxylamine,N-(o-chlorophenyl)- (7CI,8CI);N-(2-Chlorophenyl)hydroxylamine;N-(o-Chlorophenyl)hydroxylamine;N-Hydroxy-2-chloroaniline;

Chemical Property of 2-chlorophenylhydroxylamine

Chemical Property:

• Vapor Pressure: 0.0124mmHg at 25°C
• Refractive Index: 1.661
• Boiling Point: 249 °C at 760 mmHg
• Flash Point: 104.4 °C
• PSA: 32.26000
• Density: 1.409g/cm³
• LogP: 2.21410

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chlorophenylhydroxylamine

There total 8 articles about 2-chlorophenylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Chloronitrobenzene (88-73-3) → 2-chloro-N-hydroxybenzenamine (10468-16-3)

Guidance literature:

With carbon dioxide; zinc; In water; at 25 ℃; for 0.666667h; under 750.075 Torr; Sonication;

DOI:10.1007/s11164-012-0562-5

Reference yield: 73.1%

2-Chloronitrobenzene (88-73-3) → 2-chloro-N-hydroxybenzenamine (10468-16-3) + aniline (62-53-3) + o-chloroaniline (95-51-2) + 2,2'-dichloroazobenzene (7334-33-0,49795-06-4,63213-02-5) + 2,2'-azoxychlorobenzene (13556-84-8)

Guidance literature:

With bis(acetylacetonato)palladium(II); phosphorus; hydrogen; In N,N-dimethyl-formamide; benzene; at 30 ℃; for 4.1h; under 1520.1 Torr; Time; Reagent/catalyst; chemoselective reaction; Catalytic behavior;

DOI:10.1134/S0023158417010104

Reference yield: 64.3%

2-Chloronitrobenzene (88-73-3) → 2-chloro-N-hydroxybenzenamine (10468-16-3) + o-chloroaniline (95-51-2) + 2,2'-dichloroazobenzene (7334-33-0,49795-06-4,63213-02-5) + 2,2'-azoxychlorobenzene (13556-84-8)

Guidance literature:

With bis(acetylacetonato)palladium(II); phosphorus; hydrogen; In N,N-dimethyl-formamide; benzene; at 30 ℃; for 1.6h; under 1520.1 Torr; Time; Reagent/catalyst; chemoselective reaction; Catalytic behavior;

DOI:10.1134/S0023158417010104

upstream raw materials:

2-Chloronitrobenzene

benzene

o-chloroaniline

Downstream raw materials:

2,2'-dichloroazoxybenzene

2,2'-dichloroazoxybenzene

1-bromo-2-[(2-bromophenyl)-NNO-azoxy]benzene

N-(2-Chloro-phenyl)-N-hydroxy-4-nitro-benzamide

Refernces

• 1、 Kratky, Vieroslav,Kralik, Milan,Kaszonyi, Alexander,Stolcova, Magdalena,Zalibera, Lubomir,Mecarova, Miroslava,Hronec, Milan. "Reaction pathways and the role of solvent in the hydrogenation of chloronitrobenzenes". . p. 1819 - 1832. Retrieved 2003.
• 2、 -. "METHOD OF REDUCING AROMATIC NITRO COMPOUNDS". Paragraph 0332; 0342. . Retrieved 2022/02/26.
• 3、 Chen, Jian-Li,Cheng, Peng-Fei,Jiang, Zhi-Jiang,Su, Wei-Ke,Xu, Feng,Yu, Zhi-Qun. "Selective hydrogenation of nitroaromatics to: N -arylhydroxylamines in a micropacked bed reactor with passivated catalyst". . p. 28585 - 28594. Retrieved 2020/08/25.