2-[(4-CHLOROPHENYL)SULFONYL]ACETIC ACID

Base Information

• Chemical Name: 2-[(4-CHLOROPHENYL)SULFONYL]ACETIC ACID
• CAS No.: 3405-89-8
• Molecular Formula: C8H7ClO4S
• Molecular Weight: 234.66
• Mol file: 3405-89-8.mol

Synonyms:Aceticacid, [(4-chlorophenyl)sulfonyl]- (9CI);Acetic acid,[(p-chlorophenyl)sulfonyl]- (7CI,8CI);4-Chlorophenylsulfonylacetic acid;NSC203148;p-Chlorophenylsulfonylacetic acid;[(4-chlorophenyl)sulfonyl]acetic acid;NSC203148;AC1L1JKE;AC1Q768K;MolPort-000-871-060;ALBB-009423;CID55680;

Chemical Property of 2-[(4-CHLOROPHENYL)SULFONYL]ACETIC ACID

Chemical Property:

• Vapor Pressure: 1.02E-09mmHg at 25°C
• Melting Point: 121-123 °C
• Boiling Point: 472.1 °C at 760 mmHg
• Flash Point: 239.3 °C
• PSA: 79.82000
• Density: 1.52 g/cm³
• LogP: 2.27910

Purity/Quality:

99% ^*data from raw suppliers

(4-Chloro-benzenesulfonyl)-aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(4-CHLOROPHENYL)SULFONYL]ACETIC ACID

There total 12 articles about 2-[(4-CHLOROPHENYL)SULFONYL]ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chlorophenylsulfonylacetyl chloride → 2-(4-chloro-phenylsulfonyl)acetic acid (3405-89-8)

Guidance literature:

aluminium trichloride; In carbon disulfide; for 3h; Ambient temperature;

Reference yield: 93.0%

(4-chlorophenylthio)acetic acid (3405-88-7) → 2-(4-chloro-phenylsulfonyl)acetic acid (3405-89-8)

Guidance literature:

With dihydrogen peroxide; In acetic acid; 1) 20 deg C, 3h; 2) 15 min on a water bath;

Reference yield: 92.0%

sodium p-chlorobenzenesulphinate (14752-66-0) + chloroacetic acid (79-11-8) → 2-(4-chloro-phenylsulfonyl)acetic acid (3405-89-8) + 4-chlorophenyl methyl sulfone (98-57-7)

Guidance literature:

With sodium hydroxide; In water; at 100 ℃; for 1h; pH=10; Green chemistry;

DOI:10.1134/S1070427218040249

upstream raw materials:

(4-chlorophenylthio)acetic acid

ethyl 2-((4-chlorophenyl)sulfonyl)acetate

sodium p-chlorobenzenesulphinate

sodium monochloroacetic acid

Downstream raw materials:

2,4-Dichloro-1-[(E)-2-(4-chloro-benzenesulfonyl)-vinyl]-benzene

4-chlorophenyl methyl sulfone

2-Amino-1-(4-nitro-phenyl)-propane-1,3-diol; compound with (4-chloro-benzenesulfonyl)-acetic acid

ethyl 2-((4-chlorophenyl)sulfonyl)acetate

Refernces

• 1、 Adamovich,Oborina,Mirskova. "Synthesis and Pharmacological Activity of Tris(2-hydroxyethyl)ammonium 4-Chlorophenylsulfonylacetate". . p. 701 - 705. Retrieved 2018/07/06.
• 2、 Reddy, M. V. Ramana,Akula, Balireddy,Cosenza, Stephen C.,Athuluridivakar, Saikrishna,Mallireddigari, Muralidhar R.,Pallela, Venkat R.,Billa, Vinay K.,Subbaiah, D. R. C. Venkata,Bharathi, E. Vijaya,Vasquez-Del Carpio, Rodrigo,Padgaonkar, Amol,Baker, Stacey J.,Reddy, E. Premkumar. "Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7- oxo-7,8-dihydro-pyrido[2,3- d ]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5)". . p. 578 - 599. Retrieved 2014/03/21.