2'-Chloro-2,2,2-Trifluoroacetophenone

Base Information

• Chemical Name: 2'-Chloro-2,2,2-Trifluoroacetophenone
• CAS No.: 5860-95-7
• Molecular Formula: C8H4OClF3
• Molecular Weight: 208.567
• Mol file: 5860-95-7.mol

Synonyms:Ethanone, 1-(2-chlorophenyl)-2,2,2-trifluoro-

Chemical Property of 2'-Chloro-2,2,2-Trifluoroacetophenone

Chemical Property:

• Melting Point: 77-80℃
• Boiling Point: 180 °C at 760 mmHg
• Flash Point: 62.7 °C
• PSA: 17.07000
• Density: 1.308 g/cm³
• LogP: 3.08500
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2''-Chloro-2,2,2-trifluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-Chloro-2,2,2-Trifluoroacetophenone

There total 6 articles about 2'-Chloro-2,2,2-Trifluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(2-chlorophenyl)-2,2,2-trifluoroethanol (251352-64-4) → 1-(2-chlorophenyl)-2,2,2-trifluoroethan-1-one (5860-95-7)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 26h; Reflux;

DOI:10.1016/j.tetlet.2013.06.045

Reference yield:

2-chloro-benzaldehyde (89-98-5) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-(2-chlorophenyl)-2,2,2-trifluoroethan-1-one (5860-95-7)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 25 ℃;

DOI:10.1021/acs.joc.8b01672

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 1-(2-chlorophenyl)-2,2,2-trifluoroethan-1-one (5860-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

1.2: 4 h / Acidic conditions

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 26 h / Reflux

With potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2013.06.045

upstream raw materials:

trifluoroacetonitrile

2-bromo-1-chlorobenzene

1-(2-chlorophenyl)-2,2,2-trifluoroethanol

2-chloro-benzaldehyde

Refernces

• 1、 Xu, Xiao,Min, Qing-Qiang,Li, Na,Liu, Feng. "Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines". supporting information. p. 11017 - 11020. Retrieved 2018/10/08.
• 2、 Kasztelan, Adrian,Biedrzycki, Micha?,Kwiatkowski, Piotr. "High-Pressure-Mediated Asymmetric Organocatalytic Hydroxyalkylation of Indoles with Trifluoromethyl Ketones". supporting information. p. 2962 - 2969. Retrieved 2016/09/16.