O-Phenylhydroxylamine hydrochloride

Base Information

• Chemical Name: O-Phenylhydroxylamine hydrochloride
• CAS No.: 6092-80-4
• Molecular Formula: C6H7NO.ClH
• Molecular Weight: 145.589
• Hs Code.: 2922199090
• European Community (EC) Number: 228-039-0
• DSSTox Substance ID: DTXSID80209756
• Mol file: 6092-80-4.mol

Synonyms:O-Phenylhydroxylamine hydrochloride;6092-80-4;O-Phenylhydroxylamine HCl;Phenoxyamine hydrochloride;O-phenylhydroxylamine;hydrochloride;EINECS 228-039-0;Hydroxylamine, O-phenyl-, hydrochloride;MFCD00043271;N-phenoxyamine hydrochloride;SCHEMBL337034;O-Phenylhydroxylamne hydrochlorde;DTXSID80209756;DBTXKJJSFWZJNS-UHFFFAOYSA-N;o-phenyl-hydroxylamine hydrochloride;(1-Cyclopropylethyl)aminehydrochloride;AKOS016011228;AS-40150;SY116626;CS-0022011;FT-0690487;EN300-141490;J-523833;O-Phenylhydroxylamine hydrochloride, >=97.0% (AT)

Chemical Property of O-Phenylhydroxylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.504mmHg at 25°C
• Melting Point: ~132 °C (dec.)
• Boiling Point: 191.9 °C at 760 mmHg
• Flash Point: 82.5 °C
• PSA: 35.25000
• LogP: 2.44140
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 145.0294416
• Heavy Atom Count: 9
• Complexity: 59.5

Purity/Quality:

99% ^*data from raw suppliers

O-Phenylhydroxylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T; F
• Hazard Codes: F,T
• Statements: 11-25
• Safety Statements: 16-22-24/25-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)ON.Cl

Technology Process of O-Phenylhydroxylamine hydrochloride

There total 8 articles about O-Phenylhydroxylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-phenoxyisoindol-1,3-dione (64908-64-1) → phenoxyamine hydrochloride (6092-80-4)

Guidance literature:

2-phenoxyisoindol-1,3-dione; With hydrazine hydrate; In dichloromethane; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; at 0 ℃;

Reference yield: 81.5%

ethyl O-phenylacetohydroxamate (1236291-45-4) → phenoxyamine hydrochloride (6092-80-4)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃; for 2.5h;

Reference yield: 80.0%

t-butyl N-phenoxycarbamate (76570-49-5) → phenoxyamine hydrochloride (6092-80-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; nitromethane; at 0 ℃; for 1h;

DOI:10.1055/s-1988-27569

upstream raw materials:

t-butyl N-phenoxycarbamate

phenol

potassium phenolate

O-phenylhydroxylamine

Downstream raw materials:

benzophenone O-phenyl oxime

1-(2-aminophenyl)ethanone O-phenyl oxime

6-(2-pyridin-3-ylthiazol-5-yl)pyridine-2-carbaldehyde-O-phenyloxime

(2R,6S,13aS,14aR,16aS,Z)-6-(tert-butoxycarbonylamino)-5,16-dioxo-14a-(phenoxycarbamoyl)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-isoindoline-2-carboxylate

Refernces

• 1、 -. "O - substituted hydroxylamine hydrochloride and its preparation method (by machine translation)". Paragraph 0093; 0096; 0097. . Retrieved 2018/10/11.
• 2、 Contiero, Fanny,Jones, Kevin M.,Matts, Edward A.,Porzelle, Achim,Tomkinson, Nicholas C.O.. "Direct preparation of benzofurans from O-arylhydroxylamines". scheme or table. p. 3003 - 3006. Retrieved 2010/03/03.