3,4-Dichloropicolinic acid

Base Information

• Chemical Name: 3,4-Dichloropicolinic acid
• CAS No.: 959578-03-1
• Molecular Formula: C₆H₃Cl₂NO₂
• Molecular Weight: 192.001
• Hs Code.: 2933399090
• Mol file: 959578-03-1.mol

Synonyms:3,4-Dichloropicolinic acid

Chemical Property of 3,4-Dichloropicolinic acid

Chemical Property:

• Boiling Point: 316.6 °C at 760 mmHg
• PKA: 1.95±0.25(Predicted)
• Flash Point: 145.3 °C
• PSA: 50.19000
• Density: 1.612 g/cm³
• LogP: 2.08660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,4-dichloropicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dichloropicolinic acid

There total 4 articles about 3,4-Dichloropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.1%

3,4-dichloropyridine (55934-00-4) + carbon dioxide (124-38-9,18923-20-1) → 3,4-dichloropyridine-2-carboxylic acid (959578-03-1)

Guidance literature:

3,4-dichloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In diethyl ether; hexane; at -78 - 0 ℃; for 2.5h;

carbon dioxide; In diethyl ether; hexane; at -78 - 20 ℃; for 0.166667h;

With ammonium chloride; In diethyl ether; hexane; water; at 20 ℃; for 0.0833333h;

Reference yield:

3,4-dichloropyridine (55934-00-4) + carbon dioxide (124-38-9,18923-20-1) → 3,4-dichloropyridine-2-carboxylic acid (959578-03-1) + 4,5-dichloro-3-pyridinecarboxylic acid (473837-10-4)

Guidance literature:

3,4-dichloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In diethyl ether; hexane; at -75 ℃; for 2h;

carbon dioxide; at -78 ℃;

DOI:10.1002/1099-0690(200104)2001:7<1371::AID-EJOC1371>3.0.CO;2-E

Reference yield:

3,4-dichloropicolinaldehyde (1211517-04-2) → 3,4-dichloropyridine-2-carboxylic acid (959578-03-1)

Guidance literature:

With potassium permanganate; In water; acetonitrile;

DOI:10.1039/c4ob00555d

upstream raw materials:

3,4-dichloropyridine

carbon dioxide

3-Chloropyridine

3,4-dichloropicolinaldehyde

Downstream raw materials:

3,4-dichloropyridine-2-carboxamide

tert-butyl (3,4-dichloropyridin-2-yl)carbamate

BMS-777607

Refernces

• 1、 -. "Antitumor compound used as AXL inhibitor and application of antitumor compound". Paragraph 0237-0239. . Retrieved 2019/10/23.
• 2、 Schroeder, Gretchen M.,An, Yongmi,Cai, Zhen-Wei,Chen, Xiao-Tao,Clark, Cheryl,Cornelius, Lyndon A. M.,Dai, Jun,Gullo-Brown, Johnni,Gupta, Ashok,Henley, Benjamin,Hunt, John T.,Jeyaseelan, Robert,Kamath, Amrita,Kim, Kyoung,Lippy, Jonathan,Lombardo, Louis J.,Manne, Veeraswamy,Oppenheimer, Simone,Sack, John S.,Schmidt, Robert J.,Shen, Guoxiang,Stefanski, Kevin,Tokarski, John S.,Trainor, George L.,Wautlet, Barri S.,Wei, Donna,Williams, David K.,Zhang, Yingru,Zhang, Yueping,Fargnoli, Joseph,Borzilleri, Robert M.. "Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4- ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the met kinase superfamily". supporting information; experimental part. p. 1251 - 1254. Retrieved 2009/12/07.