DEAZAPURINE

Base Information

• Chemical Name: DEAZAPURINE
• CAS No.: 271-70-5
• Molecular Formula: C6H5N3
• Molecular Weight: 119.126
• Hs Code.: 2933990090
• Mol file: 271-70-5.mol

Synonyms:1H-Pyrrolo[2,3-d]pyrimidine(8CI,9CI);3H-Pyrrolo[2,3-d]pyrimidine;7-Deazapurine;NSC 94210;7H-Pyrrolo[2,3-d]pyrimidine;

Chemical Property of DEAZAPURINE

Chemical Property:

• Vapor Pressure: 0.00409mmHg at 25°C
• Melting Point: 133 °C
• Refractive Index: 1.715
• Boiling Point: 288.3 °C at 760 mmHg
• PKA: 12.79±0.20(Predicted)
• Flash Point: 141.8 °C
• PSA: 41.57000
• Density: 1.348 g/cm³
• LogP: 0.95790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform, Dichloromethane, DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

7H-Pyrrolo[2,3d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DEAZAPURINE

There total 10 articles about DEAZAPURINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 7H-pyrrolo[2,3-d]pyrimidine (271-70-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 16h; under 760.051 Torr;

Reference yield: 71.0%

(Z)-4-acetylamino-5-(2-ethoxyethenyl)pyrimidine → 7H-pyrrolo[2,3-d]pyrimidine (271-70-5)

Guidance literature:

With hydrogenchloride; In methanol; for 0.5h; Heating;

DOI:10.1248/cpb.41.81

Reference yield: 69.0%

3,7-Dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-thion (1421-27-8) → 7H-pyrrolo[2,3-d]pyrimidine (271-70-5)

Guidance literature:

nickel; In ammonium hydroxide; for 0.5h; Heating;

upstream raw materials:

3,7-Dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-thion

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

ethyl 2-cyano-4,4-diethoxybutyrate

7-deazahypoxanthine

Downstream raw materials:

5-Bromopyrrolo<2,3-d>pyrimidine

5-Iodopyrrolo<2,3-d>pyrimidine

7-deazaxanthine

7-tosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Refernces

• 1、 -. "AZAINDOLE DERIVATIVES WITH A COMBINATION OF PARTIAL NICOTINIC ACETYL-CHOLINE RECEPTOR AGONISM AND DOPAMINE REUPTAKE INHIBITION". Page/Page column 26-27. . Retrieved 2008/06/13.
• 2、 -. "DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES". Page/Page column 40; Sheet 1/9. . Retrieved 2010/11/26.