Azetidin-1-yl(5-chloropyrazin-2-yl)Methanone

Base Information

• Chemical Name: Azetidin-1-yl(5-chloropyrazin-2-yl)Methanone
• CAS No.: 915948-98-0
• Molecular Formula: C8H8ClN3O
• Molecular Weight: 197.624
• Hs Code.: 2933990090
• Mol file: 915948-98-0.mol

Synonyms:2-(azetidin-1-ylcarbonyl)-5-chloropyrazine;Azetidin-1-yl(5-chloropyrazin-2-yl)methanone;Methanone,1-azetidinyl(5-chloro-2-pyrazinyl);5-(azetidin-1-ylcarbonyl)-2-chloropyrazine;

Chemical Property of Azetidin-1-yl(5-chloropyrazin-2-yl)Methanone

Chemical Property:

• PSA: 46.09000
• LogP: 0.91380

Purity/Quality:

99.3% ^*data from raw suppliers

Azetidin-1-yl(5-chloropyrazin-2-yl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Azetidin-1-yl(5-chloropyrazin-2-yl)Methanone

There total 10 articles about Azetidin-1-yl(5-chloropyrazin-2-yl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

azetidine (503-29-7) + 5-chloropyrazinoic acid (36070-80-1) → azetidin-1-yl(5-chloropyrazin-2-yl)methanone (915948-98-0)

Guidance literature:

5-chloropyrazinoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h;

azetidine; With triethylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

azetidine (503-29-7) + 5-chloropyrazine-2-carbonyl chloride (88625-23-4) → azetidin-1-yl(5-chloropyrazin-2-yl)methanone (915948-98-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

azetidine hydrochloride (78797-58-7,78797-59-8,78797-62-3,36520-39-5,65546-09-0) + 5-chloropyrazine-2-carbonyl chloride (88625-23-4) → azetidin-1-yl(5-chloropyrazin-2-yl)methanone (915948-98-0)

Guidance literature:

azetidine hydrochloride; With triethylamine; In dichloromethane; at 20 - 25 ℃; Inert atmosphere;

5-chloropyrazine-2-carbonyl chloride; In dichloromethane; at -10 - -5 ℃; pH=> 7;

upstream raw materials:

azetidine

5-chloropyrazine-2-carbonyl chloride

azetidine hydrochloride

5-chloropyrazinoic acid

Downstream raw materials:

N,N-dimethyl-5-[3-[(3S)-1-methyl-2-oxo-pyrrolidin-3-yl]oxy-5-[(5-methylpyrazin-2-yl)carbamoyl]phenoxy]pyrazine-2-carboxamide

methyl 3-[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy-5-[(3S)-1-methyl-2-oxo-pyrrolidin-3-yl]oxy-benzoate

methyl 3-[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy-5-[(3R)-1-methyl-2-oxo-pyrrolidin-3-yl]oxy-benzoate

C₁₆H₁₅N₃O₅

Refernces

• 1、 Hose, David R. J.,Hopes, Phillip,Steven, Alan,Herber, Christian. "Redesign of the Synthesis and Manufacture of an Azetidine-Bearing Pyrazine". . p. 241 - 246. Retrieved 2018/02/23.
• 2、 -. "CRYSTALLINE POLYMORPHIC FORM 631". . . Retrieved 2010/08/22.