Glycine, N-acetyl-N-phenyl-

Base Information

• Chemical Name: Glycine, N-acetyl-N-phenyl-
• CAS No.: 579-98-6
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.202
• Hs Code.: 2924299090
• European Community (EC) Number: 209-449-9
• NSC Number: 4555,4016
• DSSTox Substance ID: DTXSID8060377
• Nikkaji Number: J95.022J
• Wikidata: Q81989085
• ChEMBL ID: CHEMBL276168
• Mol file: 579-98-6.mol

Synonyms:579-98-6;Glycine, N-acetyl-N-phenyl-;N-Acetyl-N-phenylglycine;2-(N-phenylacetamido)acetic acid;2-(N-acetylanilino)acetic acid;(acetylanilino)acetic acid;CHEMBL276168;NSC 4016;EINECS 209-449-9;Acetylphenylglycin;N-Phenylaceturic acid;acetyl-N-phenylglycine;N-acetyl phenylglycine;MLS000697353;SCHEMBL690247;2-(N-phenylacetamido)aceticacid;DTXSID8060377;NSC4016;NSC4555;(Acetyl-phenyl-amino)-acetic acid;HMS1654M20;HMS2562I16;ADAL1013026;NSC-4016;NSC-4555;BDBM50016599;MFCD01234351;AKOS000272894;NCGC00246616-01;SMR000238011;CS-0237080;EN300-177663;AG-205/01756016;Z57724160

Chemical Property of Glycine, N-acetyl-N-phenyl-

Chemical Property:

• Vapor Pressure: 7.39E-06mmHg at 25°C
• Boiling Point: 361.5°Cat760mmHg
• Flash Point: 172.4°C
• PSA: 57.61000
• Density: 1.269g/cm³
• LogP: 1.12410
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 193.07389321
• Heavy Atom Count: 14
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

(ACETYL-PHENYL-AMINO)-ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(CC(=O)O)C1=CC=CC=C1

Technology Process of Glycine, N-acetyl-N-phenyl-

There total 13 articles about Glycine, N-acetyl-N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-acetyl-N-phenylglycine methyl ester (851679-97-5) → N-acetyl-N-phenylglycine (579-98-6,116306-61-7)

Guidance literature:

N-acetyl-N-phenylglycine methyl ester; With lithium hydroxide; water; In tetrahydrofuran; methanol; water; at 20 ℃;

With hydrogenchloride; In water; pH=1;

Reference yield: 73.5%

→ N-acetyl-N-phenylglycine (579-98-6,116306-61-7)

Guidance literature:

Reference yield: 65.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + carbon monoxide (201230-82-2) + Acetanilid (103-84-4) → N-acetyl-N-phenylglycine (579-98-6,116306-61-7)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sulfuric acid; lithium bromide; palladium on activated charcoal; at 130 ℃; for 60h; under 45003.6 Torr;

DOI:10.1016/S0040-4039(99)00801-1

upstream raw materials:

N-(2-butenyl)acetanilide

acetic anhydride

N-Phenylglycine

sodium acetate

Downstream raw materials:

4-trifluoroacetyl-2-methyl-3-phenyl-1,3-oxazol-3-ium-5-olate

indoxyl

N-acetyl-N-phenylglycine N-hydroxysuccinimide ester

ethyl 2-(N-phenyl-2-(N-phenylacetamido)acetamido)acetate

Refernces

• 1、 -. "Amide derivatives and methods of their use". Page/Page column 30. . Retrieved 2008/06/13.
• 2、 DeRuiter, Jack,Swearingen, Blake E.,Wandrekar, Vinay,Mayfield, Charles A.. "Synthesis and in Vitro Aldolase Reductase Inhibitory Activity of Compounds Containing an N-Acylglycine Moiety". . p. 1033 - 1038. Retrieved 2007/10/02.