Octanoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-

Base Information

• Chemical Name: Octanoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-
• CAS No.: 888725-91-5
• Molecular Formula: C23H27NO4
• Molecular Weight: 381.472
• Mol file: 888725-91-5.mol

Synonyms:

Chemical Property of Octanoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-

Chemical Property:

Purity/Quality:

≥98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Octanoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-

There total 3 articles about Octanoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H25NO4 → Fmoc-L-2-Aoc-OH (888725-91-5,888725-90-4)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; under 3102.97 Torr;

DOI:10.1002/psc.2522

Reference yield:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid (146549-21-5) → Fmoc-L-2-Aoc-OH (888725-91-5,888725-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 20 °C / Inert atmosphere; Schlenk technique

2: hydrogen / methanol / 20 °C / 3102.97 Torr

With Hoveyda-Grubbs catalyst second generation; hydrogen; In methanol; dichloromethane;

DOI:10.1002/psc.2522

Reference yield:

→ Fmoc-L-2-Aoc-OH (888725-91-5,888725-90-4)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; under 3102.97 Torr;

upstream raw materials:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid

Downstream raw materials:

9H-fluoren-9-ylmethyl {(2S)-1-oxo-1-[(2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]octan-2-yl}carbamate

Refernces

• 1、 Wang, Zhen J.,Spiccia, Nicolas D.,Jackson, W. Roy,Robinson, Andrea J.. "Tandem Ru-alkylidene-catalysed cross metathesis/hydrogenation: Synthesis of lipophilic amino acids". . p. 470 - 476. Retrieved 2013/08/23.