2-anilino-2-(2-pyridinyl)propanenitrile

Base Information

• Chemical Name: 2-anilino-2-(2-pyridinyl)propanenitrile
• CAS No.: 17424-73-6
• Molecular Formula: C14H13N3
• Molecular Weight: 223.27
• Mol file: 17424-73-6.mol

Synonyms:2-Anilino-2-pyridin-2-yl-propanenitrile;2-(Phenylamino)-2-(pyridin-2-yl)propanenitrile;

Chemical Property of 2-anilino-2-(2-pyridinyl)propanenitrile

Chemical Property:

• Vapor Pressure: 2.33E-06mmHg at 25°C
• Refractive Index: 1.624
• Boiling Point: 392.2 °C at 760 mmHg
• Flash Point: 191 °C
• PSA: 48.71000
• Density: 1.174 g/cm³
• LogP: 3.00548

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-anilino-2-(2-pyridinyl)propanenitrile

There total 3 articles about 2-anilino-2-(2-pyridinyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-acetylpyridine (1122-62-9) + potassium cyanide (151-50-8) + aniline (62-53-3) → 2-(phenylamino)-2-(pyridin-2-yl)propanenitrile (17424-73-6)

Guidance literature:

With acetic acid; a) 0 deg C, 4-5 h, b) RT, overnight;

DOI:10.1002/jhet.5570360234

Reference yield:

2-acetylpyridine (1122-62-9) + trimethylsilyl cyanide (7677-24-9) + aniline (62-53-3) → 2-(phenylamino)-2-(pyridin-2-yl)propanenitrile (17424-73-6)

Guidance literature:

With C₂₅H₂₄N₄O₄*2C₁₆H₁₄O₄Si^(2-)*2Zn⁽²⁺⁾*2H₂O; In neat (no solvent); at 25 - 30 ℃; for 5h; Catalytic behavior; Inert atmosphere;

DOI:10.1021/acs.inorgchem.9b03051

Reference yield:

→ 2-(phenylamino)-2-(pyridin-2-yl)propanenitrile (17424-73-6)

Guidance literature:

1-(2-Pyridyl)-ethanon, Anilin, CN-Ion (Ggw. v. Eg.);

upstream raw materials:

2-acetylpyridine

potassium cyanide

aniline

trimethylsilyl cyanide

Refernces

• 1、 Schnell, Barbara. "Synthesis and reactions of 4-hydroxy-2(1H)-pyridones with thienyl and pyridyl substituents in position 6 starting with azomethines and malonates". . p. 541 - 548. Retrieved 2007/10/03.