4-Chloro-6-hydrazinopyrimidine

Base Information

• Chemical Name: 4-Chloro-6-hydrazinopyrimidine
• CAS No.: 5767-35-1
• Molecular Formula: C4H5 Cl N4
• Molecular Weight: 144.564
• Hs Code.: 2933990090
• Mol file: 5767-35-1.mol

Synonyms:4(1H)-Pyrimidinone, 6-chloro-, hydrazone(9CI); Pyrimidine, 4-chloro-6-hydrazino- (7CI,8CI);4-Chloro-6-hydrazinopyrimidine; NSC 61591

Chemical Property of 4-Chloro-6-hydrazinopyrimidine

Chemical Property:

• Appearance/Colour: White to off-white crystalline powder
• Melting Point: 164-165 °C
• Boiling Point: 328.3 °C at 760 mmHg
• PKA: 7.29±0.70(Predicted)
• Flash Point: 152.4 °C
• PSA: 63.83000
• Density: 1.53 g/cm³
• LogP: 1.18890
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-6-hydrazinopyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-6-hydrazinopyrimidine

There total 2 articles about 4-Chloro-6-hydrazinopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4,6-dichloropyrimidine (1193-21-1) → 6-chloro-4-hydrazinopyrimidine (5767-35-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 1.5h;

DOI:10.1016/j.molstruc.2018.08.018

Reference yield:

→ 6-chloro-4-hydrazinopyrimidine (5767-35-1)

Guidance literature:

Reference yield: 85.0%

6-chloro-4-hydrazinopyrimidine (5767-35-1) + benzaldehyde (100-52-7) → benzaldehyde (6-chloro-4-pyrimidinyl)hydrazone (68588-40-9)

Guidance literature:

In ethanol; at 20 ℃; for 1h;

DOI:10.3762/bjoc.9.298

upstream raw materials:

4,6-dichloropyrimidine

Downstream raw materials:

4-(6-hydrazinopyrimidin-4-yl)morpholine

pyrimidin-4-ylhydrazine

(6-methylsulfanylpyrimidin-4-yl)hydrazine

C₈H₈ClN₅

Refernces

• 1、 Hasi, Qi-Meige,Fan, Yan,Feng, Xiao-Xia,Yao, Xiao-Qiang,Liu, Jia-Cheng. "Antioxidant and antimicrobial properties of nickel(II), cobalt(III), and zinc(II) complexes of a Schiff base ligand". . p. 685 - 692. Retrieved 2016.
• 2、 -. "ErbB RECEPTOR INHIBITORS AS ANTI-TUMOR AGENTS". Page/Page column 132; 133. . Retrieved 2021/09/17.