2,4,6-TRIMETHOXY-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 2,4,6-TRIMETHOXY-BENZOIC ACID METHYL ESTER
• CAS No.: 29723-28-2
• Molecular Formula: C11H14O5
• Molecular Weight: 226.229
• Hs Code.: 2918990090
• Mol file: 29723-28-2.mol

Synonyms:Methyl 2,4,6-trimethoxybenzoate;NSC 151971;

Chemical Property of 2,4,6-TRIMETHOXY-BENZOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 6.85E-05mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 152 °C
• PSA: 53.99000
• Density: 1.134 g/cm³
• LogP: 1.49900

Purity/Quality:

99.5% ^*data from raw suppliers

METHYL 2,4,6-TRIMETHOXYBENZOATE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,4,6-TRIMETHOXY-BENZOIC ACID METHYL ESTER

There total 17 articles about 2,4,6-TRIMETHOXY-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acide 2,4,6-trihydroxybenzoique (83-30-7) + dimethyl sulfate (77-78-1) → methyl 2,4,6-trimethoxybenzoate (29723-28-2)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; Molecular sieve;

DOI:10.1002/chem.201203149

Reference yield: 54.0%

tert.-butylhydroperoxide (75-91-2) + 2,4,6-trimethoxybenzaldehyde (830-79-5) → methyl 2,4,6-trimethoxybenzoate (29723-28-2)

Guidance literature:

With copper (II)-fluoride; In water; dimethyl sulfoxide; at 120 ℃; for 12h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1016/j.tetlet.2013.11.040

Reference yield:

methanol (67-56-1) + 2,4,6-trimethoxybenzoic acid (570-02-5) → methyl 2,4,6-trimethoxybenzoate (29723-28-2)

Guidance literature:

With sulfuric acid; for 24h; Reflux;

upstream raw materials:

diazomethane

acide 2,4,6-trihydroxybenzoique

dimethyl sulfate

2,2,2-trichloro-1-(2,4-dihydroxy-6-methoxy-phenyl)-ethanone

Downstream raw materials:

2,4,6-trimethoxybenzoic acid

3-chloro-2,4,6-trimethoxy-benzoic acid methyl ester

1-(2,4,6-trimethoxyphenyl)-1,3,5,7-octanetetraone

1-(2,4,6-trimethoxyphenyl)-1,3,5-hexanetrione

Refernces

• 1、 -. "INFECTION INDICATING MEDICAL DEVICES". Paragraph 0082. . Retrieved 2015/02/19.
• 2、 Bielitza, Max,Pietruszka, J?rg. "Synthesis of 8-desmethoxy psymberin: A putative biosynthetic intermediate towards the marine polyketide psymberin". supporting information. p. 8300 - 8308. Retrieved 2013/07/25.