1H-Indene-2-carboxylic acid, 6-hydroxy-1-oxo-3-phenyl-, ethyl ester

Base Information

• Chemical Name: 1H-Indene-2-carboxylic acid, 6-hydroxy-1-oxo-3-phenyl-, ethyl ester
• CAS No.: 867187-58-4
• Molecular Formula: C18H14O4
• Molecular Weight: 294.307
• Mol file: 867187-58-4.mol

Synonyms:

Chemical Property of 1H-Indene-2-carboxylic acid, 6-hydroxy-1-oxo-3-phenyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indene-2-carboxylic acid, 6-hydroxy-1-oxo-3-phenyl-, ethyl ester

There total 6 articles about 1H-Indene-2-carboxylic acid, 6-hydroxy-1-oxo-3-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-ethoxycarbonyl-6-methoxy-3-phenylindenone (850209-49-3) → 1-oxo-6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (867187-58-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/chem.201202534

Reference yield: 86.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 6-hydroxy-3-phenylinden-1-one → 1-oxo-6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (867187-58-4)

Guidance literature:

With palladium diacetate; triphenylphosphine; cesium fluoride; at 125 ℃; for 4h; under 7600.51 Torr; Inert atmosphere;

DOI:10.1246/cl.2008.1068

Reference yield: 61.0%

6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (867187-57-3) → 1-oxo-6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (867187-58-4)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 10h; Heating / reflux;

upstream raw materials:

6-hydroxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

2-(3-hydroxybenzyl)-3-oxo-3-phenylpropionic acid ethyl ester

ethyl 3-oxo-3-phenylpropionate

3-hydroxybenzyl chloride

Downstream raw materials:

ethyl 1-oxo-3-phenyl-6-(prop-2-ynyloxy)-1H-indene-2-carboxylate

ethyl 6-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-1-oxo-3-phenyl-1H-indene-2-carboxylate

ethyl 6-[2-(2-methoxyethoxy)ethoxy]-1-oxo-3-phenyl-1H-indene-2-carboxylate

ethyl 6-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yloxy)-1-oxo-3-phenyl-1H-indene-2-carboxylate

Refernces

• 1、 Yum, Eul Kgun,Park, Woul Seong,Kim, Se Hoan,Kang, Seung Kyu,Kim, Sung Soo,Ahn, Jin Hee. "Facile synthesis of alkyl 1-oxo-3-phenyl-1H-indene-2-earboxylate through palladium-catalyzed carboalkoxylation from 2-bromo-3-phenylinden-1-ones". supporting information; experimental part. p. 1068 - 1069. Retrieved 2009/12/03.
• 2、 -. "INDENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF". Page/Page column 23. . Retrieved 2008/06/13.