2,N-DIHYDROXY-BENZAMIDINE

Base Information

• Chemical Name: 2,N-DIHYDROXY-BENZAMIDINE
• CAS No.: 6005-58-9
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 2925290090
• Mol file: 6005-58-9.mol

Synonyms:Salicylamidoxime(6CI,7CI,8CI);Salicylamide, oxime;o-Hydroxybenzamidoxime;2-Hydroxy-benzamide oxime;2,N-Dihydroxy-benzamidine;

Chemical Property of 2,N-DIHYDROXY-BENZAMIDINE

Chemical Property:

• Melting Point: 80-84℃
• Boiling Point: 366.8 °C at 760 mmHg
• Flash Point: 175.6 °C
• PSA: 76.34000
• Density: 1.35 g/cm³
• LogP: 1.18700

Purity/Quality:

98%Min ^*data from raw suppliers

2-HydroxybenzamideOxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,N-DIHYDROXY-BENZAMIDINE

There total 5 articles about 2,N-DIHYDROXY-BENZAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

salicylonitrile (611-20-1) → N',2-dihydroxybenzimidamide (6005-58-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In methanol; for 24h; Reflux;

Reference yield:

salicylonitrile (611-20-1) + hydroxylamine hydrochloride (5470-11-1) → 2-Hydroxy-benzamide oxime (6005-58-9,849833-62-1)

Guidance literature:

With sodium methylate; In methanol; water;

Reference yield:

salicylamide (65-45-2) → N',2-dihydroxybenzimidamide (6005-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentoxide

2: alcohol; sodium carbonate; hydroxylamine hydrochloride / 90 °C / unter Druck

With phosphorus pentaoxide; ethanol; hydroxylamine hydrochloride; sodium carbonate;

upstream raw materials:

salicylonitrile

salicylamide

2-hydroxy-benzoic acid ethyl ester

hydroxylamine hydrochloride

Downstream raw materials:

N-ethoxycarbonyloxy-salicylamidine

3-(o-hydroxyphenyl)-1,2,4-oxadiazole

N-benzoyloxy-salicylamidine

hydroxybenzamidine

Refernces

• 1、 Buommino, Elisabetta,D’auria, Maria Valeria,De Marino, Simona,Festa, Carmen,Piccolo, Marialuisa,Sciarretta, Martina. "Synergism of a novel 1,2,4-oxadiazole-containing derivative with oxacillin against methicillin-resistant staphylococcus aureus". . . Retrieved 2021/11/01.
• 2、 -. "Compound and application of compound in preparation of medicines". Paragraph 0173; 0174; 0292. . Retrieved 2016/10/08.