8-BROMO-NAPHTHALEN-2-OL

Base Information

• Chemical Name: 8-BROMO-NAPHTHALEN-2-OL
• CAS No.: 7385-87-7
• Molecular Formula: C10H7BrO
• Molecular Weight: 223.069
• Hs Code.: 2908199090
• Mol file: 7385-87-7.mol

Synonyms:2-Naphthol,8-bromo;8-bromanylnaphthalen-2-ol;1-bromo-7-naphthol;8-Bromo-2-Naphthalenol;7-hydroxy-1-bromo-naphthalene;8-Bromo-2-naphthol;8-Brom-2-hydroxy-naphthalin;8-bromo-naphtol;8-Brom-<2>naphthol;

Chemical Property of 8-BROMO-NAPHTHALEN-2-OL

Chemical Property:

• Melting Point: 113-114 °C
• Boiling Point: 353.8±15.0 °C(Predicted)
• PKA: 9.12±0.40(Predicted)
• PSA: 20.23000
• Density: 1.614±0.06 g/cm3(Predicted)
• LogP: 3.30790
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

8-bromonaphthalen-2-ol 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMO-NAPHTHALEN-2-OL

There total 12 articles about 8-BROMO-NAPHTHALEN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(+)-cis-(1R,2S)-dihydroxy-1,2-dihydro-8-bromonaphthalene → 8-bromo-naphthalene-2-ol (7385-87-7)

Guidance literature:

With hydrogenchloride; In methanol; Ambient temperature;

DOI:10.1016/0957-4166(95)00421-1

Reference yield: 45.0%

8-amino-2-naphthol (118-46-7) → 8-bromo-naphthalene-2-ol (7385-87-7)

Guidance literature:

With hydrogen bromide; copper(I) bromide; sodium nitrite; In water; acetonitrile; at 20 ℃; for 16h;

Reference yield: 20.0%

naphthalen-2-yl tosylate (7385-85-5) → 8-bromo-naphthalene-2-ol (7385-87-7)

Guidance literature:

naphthalen-2-yl tosylate; With bromine; iron; acetic acid; for 20h; Reflux;

With sodium hydroxide; In tetrahydrofuran; ethanol; water; for 20h; Reflux;

DOI:10.1021/acs.orglett.7b02305

upstream raw materials:

8-bromo-2-benzoyloxynaphthalene

8-amino-2-naphthol

p-Toluolsulfonsaeure-<8-brom-naphthyl-(2)-ester>

naphthalen-2-yl tosylate

Downstream raw materials:

7-hydroxy-1-naphthaldehyde

Refernces

• 1、 Di Iorio, Nicola,Filippini, Giacomo,Mazzanti, Andrea,Righi, Paolo,Bencivenni, Giorgio. "Controlling the C(sp3)-C(sp2) Axial Conformation in the Enantioselective Friedel-Crafts-Type Alkylation of β-Naphthols with Inden-1-ones". supporting information. p. 6692 - 6695. Retrieved 2017/12/26.
• 2、 -. "COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS". Page/Page column 82. . Retrieved 2014/03/21.