1-METHYL-1H-IMIDAZOLE-2-CARBONYL CHLORIDE,97%

Base Information

• Chemical Name: 1-METHYL-1H-IMIDAZOLE-2-CARBONYL CHLORIDE,97%
• CAS No.: 62366-45-4
• Molecular Formula: C5H5ClN2O
• Molecular Weight: 144.56
• Hs Code.: 2933290090
• Mol file: 62366-45-4.mol

Synonyms:1-methyl-1H-imidazole-2-carboxylic acid chloride;1H-Imidazole-2-carbonyl chloride,1-methyl;N-methyl-2-imidazoylchloride;1-Methyl-1H-Imidazole-2-Carbonyl Chloride;

Chemical Property of 1-METHYL-1H-IMIDAZOLE-2-CARBONYL CHLORIDE,97%

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 67.7oC
• Boiling Point: 275.136oC at 760 mmHg
• PKA: 2.81±0.25(Predicted)
• Flash Point: 120.198oC
• PSA: 34.89000
• Density: 1.37g/cm3
• LogP: 0.79910

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-METHYL-1H-IMIDAZOLE-2-CARBONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-1H-IMIDAZOLE-2-CARBONYL CHLORIDE,97%

There total 1 articles about 1-METHYL-1H-IMIDAZOLE-2-CARBONYL CHLORIDE,97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-2-imidazolecarboxylic acid (20485-43-2) → 1-methyl-1H-imidazole-2-carboxylic acid chloride (62366-45-4)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1h; Heating;

DOI:10.1016/j.bmcl.2006.12.083

Reference yield: 77.2%

1-methyl-1H-imidazole-2-carboxylic acid chloride (62366-45-4) + 1-benzyl-5-amino-1H-indole-3-carbonitrile → N-(1-benzyl-3-cyano-1H-indol-5-yl)-1-methyl-1H-imidazole-2-carboxamide

Guidance literature:

With triethylamine; In tetrahydrofuran; at -5 - 20 ℃;

DOI:10.1016/j.bioorg.2021.105417

Reference yield:

1-methyl-1H-imidazole-2-carboxylic acid chloride (62366-45-4) + 3-Carboxyphenol (99-06-9) → C12H12N2O3 (1094382-03-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

1-methyl-2-imidazolecarboxylic acid

Downstream raw materials:

C₁₂H₁₂N₂O₃

N-[4-(3,4-dimethoxyphenyl)-2-thienyl]-1-methylimidazole-2-carboxamide

Refernces

• 1、 Raoof, Ali,Depledge, Paul,Hamilton, Niall M.,Hamilton, Nicola S.,Hitchin, James R.,Hopkins, Gemma V.,Jordan, Allan M.,Maguire, Laura A.,McGonagle, Alison E.,Mould, Daniel P.,Rushbrooke, Mathew,Small, Helen F.,Smith, Kate M.,Thomson, Graeme J.,Turlais, Fabrice,Waddell, Ian D.,Waszkowycz, Bohdan,Watson, Amanda J.,Ogilvie, Donald J.. "Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II". . p. 6352 - 6370. Retrieved 2013/09/23.
• 2、 Kulkarni, Santosh S.,Newman, Amy Hauck. "Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists". . p. 2074 - 2079. Retrieved 2007/10/03.