2-Methoxypyridine

Base Information

• Chemical Name: 2-Methoxypyridine
• CAS No.: 1628-89-3
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Hs Code.: 29339900
• European Community (EC) Number: 216-623-8
• UNII: GEB38J8108
• DSSTox Substance ID: DTXSID60862722
• Nikkaji Number: J7.535C
• Wikidata: Q27279065
• ChEMBL ID: CHEMBL3274300
• Mol file: 1628-89-3.mol

Synonyms:2-METHOXYPYRIDINE;1628-89-3;Pyridine, 2-methoxy-;Pyridine, methoxy-;2-methoxy-pyridine;UNII-GEB38J8108;2-Methoxy pyridine;GEB38J8108;EINECS 216-623-8;AI3-62040;methoxypyridine;6-methoxypyridine;MFCD00006262;methyl pyridinyl ether;2-Methoxypyridine, 98%;SCHEMBL65664;CHEMBL3274300;FEMA NO. 4639;DTXSID60862722;BCP23284;STR07505;BBL011495;STL146607;AKOS005721111;CS-W009307;PS-9275;AC-15188;AM20050859;FT-0612869;M0788;EN300-55187;A810421;Q-100196;Q27279065

Chemical Property of 2-Methoxypyridine

Chemical Property:

• Appearance/Colour: Clear colorless to slightly yellow liquid
• Vapor Pressure: 7.11mmHg at 25°C
• Refractive Index: n20/D 1.503(lit.)
• Boiling Point: 142.1 °C at 760 mmHg
• PKA: 3.28(at 20℃)
• Flash Point: 47.9 °C
• PSA: 22.12000
• Density: 1.023 g/cm³
• LogP: 1.09020
• Storage Temp.: Flammables area
• Water Solubility.: INSOLUBLE
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 65.5

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,F
• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 26-36-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: COC1=CC=CC=N1

Technology Process of 2-Methoxypyridine

There total 82 articles about 2-Methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-pyridine (109-04-6) + methanol (67-56-1) → 2-methoxypyridine (1628-89-3)

Guidance literature:

With sodium hydroxide;

Reference yield: 87.0%

2-aminopyridine (504-29-0) + trimethyl orthoformate (149-73-5) → 2-methoxypyridine (1628-89-3)

Guidance literature:

With tert.-butylnitrite; at 40 - 60 ℃; for 1h;

Reference yield: 78.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) → 2-methoxypyridine (1628-89-3)

Guidance literature:

With methanol; magnesium; at 20 ℃;

DOI:10.1016/j.tetlet.2018.07.008

upstream raw materials:

diazomethane

2-Pyridone

2-hydroxypyridin

methanol

Downstream raw materials:

2-methoxypyridine N-oxide

(2-oxo-2H-pyridin-1-yl)-acetic acid

2-methoxy-1-methyl-pyridinium; toluene-4-sulfonate

2-methoxy-5-nitropyridine

Refernces

• 1、 -. "Preparation method of ortho-alkoxy substituted pyridine compound". Paragraph 0052-0056. . Retrieved 2021/09/08.
• 2、 Korvinson, Kirill A.,Akula, Hari K.,Malinchak, Casina T.,Sebastian, Dellamol,Wei, Wei,Khandaker, Tashrique A.,Andrzejewska, Magdalena R.,Zajc, Barbara,Lakshman, Mahesh K.. "Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine". supporting information. p. 166 - 176. Retrieved 2020/01/02.