4-Amino-3-methoxyphenol

Base Information

• Chemical Name: 4-Amino-3-methoxyphenol
• CAS No.: 61638-01-5
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID00600281
• Nikkaji Number: J90.169E
• Wikidata: Q72438792
• Mol file: 61638-01-5.mol

Synonyms:4-AMINO-3-METHOXYPHENOL;61638-01-5;MFCD00272194;Phenol, 4-amino-3-methoxy-;SCHEMBL282092;DTXSID00600281;SXJQUUPSLJTKKT-UHFFFAOYSA-N;AKOS005263973;MB01122;AS-31544;SY006410;DB-072995;EN300-182081;A868662

Chemical Property of 4-Amino-3-methoxyphenol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 315.892oC at 760 mmHg
• Flash Point: 144.847oC
• PSA: 55.48000
• Density: 1.219g/cm3
• LogP: 1.56420
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-3-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)O)N

Technology Process of 4-Amino-3-methoxyphenol

There total 16 articles about 4-Amino-3-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(benzyloxy)-2-methoxy-1-nitrobenzene (864245-30-7) → 4-Amino-3-methoxyphenol (61638-01-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield: 99.0%

4-nitro-3-methoxyphenol (16292-95-8) → 4-Amino-3-methoxyphenol (61638-01-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.07.042

Reference yield: 66.0%

O-methylresorcine (150-19-6) + 4-aminobenzene sulfonic acid (121-57-3,856062-06-1) → 4-Amino-3-methoxyphenol (61638-01-5)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium carbonate; sodium nitrite; In water;

upstream raw materials:

O-methylresorcine

2-Nitroanisole

methoxy-[1,4]benzoquinone-1-oxime

4-benzenesulfonic acid

Downstream raw materials:

C₃₇H₄₁NO₁₁S

N-(4-hydroxy-2-methoxyphenyl)methanesulfonamide

4-(4-amino-3-methoxyphenoxy)-3-nitropyridin-2-ylamine

C₁₄H₁₅NO₄S

Refernces

• 1、 Safari,Gandomi-Ravandi,Haghighi. "Supported polymer magnets with high catalytic performance in the green reduction of nitroaromatic compounds". . p. 31514 - 31525. Retrieved 2016/04/08.
• 2、 Leriche, Geoffray,Budin, Ghyslain,Brino, Laurent,Wagner, Alain. "Optimization of the azobenzene scaffold for reductive cleavage by dithionite; development of an azobenzene cleavable linker for proteomic applications". experimental part. p. 4360 - 4364. Retrieved 2010/09/20.