Phosphonic acid, phenyl-, monoethyl ester

Base Information

• Chemical Name: Phosphonic acid, phenyl-, monoethyl ester
• CAS No.: 4546-19-4
• Molecular Formula: C8H11O3P
• Molecular Weight: 186.147
• Mol file: 4546-19-4.mol

Synonyms:

Chemical Property of Phosphonic acid, phenyl-, monoethyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, phenyl-, monoethyl ester

There total 39 articles about Phosphonic acid, phenyl-, monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diethyl phenylphosphonate (1754-49-0) → ethyl hydrogen phenylphosphonate (4546-19-4)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 20h;

DOI:10.1021/ol0066330

Reference yield: 90.0%

O-ethyl phenylphosphonochloridothioate (5075-13-8) → ethyl hydrogen phenylphosphonate (4546-19-4) + O-ethyl phenylphosphonothioic acid (6230-93-9)

Guidance literature:

With water; N,N-dimethyl-formamide; In tetrachloromethane;

DOI:10.1016/S0040-4020(01)83131-8

Reference yield: 70.0%

ethanol (64-17-5) + phenylphosphonate (1571-33-1) → diethyl phenylphosphonate (1754-49-0) + ethyl hydrogen phenylphosphonate (4546-19-4)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 165 ℃; for 8h; under 750.075 - 13501.4 Torr; Reagent/catalyst; Microwave irradiation; Sealed tube; Green chemistry;

DOI:10.1080/00397911.2019.1637894

upstream raw materials:

phenyltetrachlorophosphorane

ethanol

2,4-diphenyl-cyclodiphosphoxane-2,4-dioxide

(S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester

Downstream raw materials:

O-ethyl-1-hydroxypropyl-phenylphosphinate

ethyl o-phenyl phenylphosphonate

diethyl phenylphosphonate

dioctyl phenylphosphonate

Refernces

• 1、 Ash, Jeffrey,Cordero, Paula,Huang, Hai,Kang, Jun Yong. "Selective hydrolysis of phosphorus(v) compounds to form organophosphorus monoacids". . p. 6007 - 6014. Retrieved 2021/07/21.
• 2、 Brodzka, Anna,Koszelewski, Dominik,Ostaszewski, Ryszard,Trzepizur, Damian. "Selective esterification of phosphonic acids". . . Retrieved 2021/09/27.