3-bromooxolane-2,5-dione

Base Information

• Chemical Name: 3-bromooxolane-2,5-dione
• CAS No.: 5470-44-0
• Molecular Formula: C4H3 Br O3
• Molecular Weight: 178.97
• Hs Code.: 2917190090
• Mol file: 5470-44-0.mol

Synonyms:2,5-Furandione,3-bromodihydro-, (?à)-; Succinic anhydride, bromo- (6CI,7CI); (?à)-Bromosuccinic anhydride; Bromosuccinic acid anhydride;Bromosuccinic anhydride; NSC 25300; a-Bromosuccinic acid anhydride

Chemical Property of 3-bromooxolane-2,5-dione

Chemical Property:

• Vapor Pressure: 0.00134mmHg at 25°C
• Boiling Point: 297.5°Cat760mmHg
• Flash Point: 133.7°C
• PSA: 43.37000
• Density: 2.054g/cm³
• LogP: 0.22340

Purity/Quality:

99% ^*data from raw suppliers

3-bromodihydro-2,5-Furandione 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromooxolane-2,5-dione

There total 6 articles about 3-bromooxolane-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bromosuccinic acid (923-06-8,584-98-5) → 3-bromodihydro-2,5-furandione (5470-44-0)

Guidance literature:

With acetic anhydride; for 2h; Heating;

DOI:10.1016/j.bmc.2005.11.045

Reference yield:

maleic anhydride (108-31-6) → 3-bromodihydro-2,5-furandione (5470-44-0) + 1,2-Dibromosuccinic anhydride (45669-18-9,1122-11-8) + 2,3-Dibromo-succinic acid monomethyl ester (85145-47-7) + monomethyl maleate (3052-50-4)

Guidance literature:

With bromine; In dichloromethane; Product distribution; various solvents, also in methanol;

DOI:10.1007/BF00765255

Reference yield:

succinic acid anhydride (108-30-5) + bromine (7726-95-6) → 3-bromodihydro-2,5-furandione (5470-44-0) + 2,3-dibromomaleic anhydride (1122-12-9)

Guidance literature:

at 100 ℃;

DOI:10.1039/jr9300001733

upstream raw materials:

bromosuccinic acid

Acetyl bromide

(2E)-but-2-enedioic acid

maleic anhydride

Downstream raw materials:

succinic acid anhydride

(RS)-benzyl β-malolactonate

RS-3-benzyloxycarbonyl-3-bromopropanoic acid

2-bromo-succinic acid 4-benzyl ester

Refernces

• 1、 Bizzarri, Ranieri,Chiellini, Federica,Solaro, Roberto,Chiellini, Emo,Cammas-Marion, Sandrine,Guerin, Philippe. "Synthesis and characterization of new malolactonate polymers and copolymers for biomedical applications". . p. 1215 - 1223. Retrieved 2002.
• 2、 Yang, Xiaoqiang,Grailer, Jamison J.,Pilla, Srikanth,Steeber, Douglas A.,Gong, Shaoqin. "Tumor-targeting, pH-responsive, and stable unimolecular micelles as drug nanocarriers for targeted cancer therapy". experimental part. p. 496 - 504. Retrieved 2011/01/03.
• 3、 -. "Tocopherol ester compounds". Page column 4. . Retrieved 2010/02/06.