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Cas Database |
| Name |
K-Strophanthidine |
EINECS | 200-626-6 |
| CAS No. | 66-28-4 | Density | 1.432 g/cm3 |
| PSA | 104.06000 | LogP | 1.89820 |
| Solubility | N/A | Melting Point |
169°C |
| Formula | C23H32 O6 | Boiling Point | 620.7 °C at 760 mmHg |
| Molecular Weight | 404.503 | Flash Point | 214.9 °C |
| Transport Information | UN 2811 6 | Appearance | N/A |
| Safety | A deadly poison by intravenous routes. When heated to decomposition it emits acrid smoke and irritating fumes. | Risk Codes | 26/27/28 |
| Molecular Structure |
|
Hazard Symbols |
 T+
|
| Synonyms |
5b-Card-20(22)-enolide, 3b,5,14-trihydroxy-19-oxo-(7CI,8CI); Strophanthidin (6CI); Apocymarin; Convallatoxigenin; Corchorin;Corchoside A aglycon; Corchsularin; Erysimupicrone; Erysimupikron; NSC 86078;Strophanthidin K; Strophanthidine; k-Strophanthidin |
Article Data | 18 |
K-Strophanthidine Chemical Properties
IUPAC Name: (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-Trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
CAS: 66-28-4
EINECS: 200-626-6
Following is the Molecular Structure of K-Strophanthidine (66-28-4):
SMILES: O=C/1OCC(=C\1)\[C@@H]2[C@@]4([C@](O)(CC2)[C@@H]5CC[C@]3(O)C[C@@H](O)CC[C@]3(C=O)[C@H]5CC4)C
InChI: InChI=1/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1
InChIKey: ODJLBQGVINUMMR-HZXDTFASBJ
Std.InChI: InChI=1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1
Std.InChIKey: ODJLBQGVINUMMR-HZXDTFASSA-N
Molecular Formula: C23H32O6
Molecular Weight: 404.5
Melting Point: 169℃
Boiling Point: 620.7℃ at 760mmHg
Flash Point: 214.9℃
Molar Volume: 282.3cm3
Density: 1.432g/cm3
Molar Refractivity: 106.07cm3
Surface Tension: 82.1dyne/cm
Polarizability: 42.05 10-24cm3
Enthalpy of Vaporization: 105.46kJ/mol
Vapour Pressure: 5.25E-18mmHg at 25℃
K-Strophanthidine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intravenous | 224ug/kg (0.224mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 420, 1951. | |
| cat | LDLo | unreported | 260ug/kg (0.26mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964. | |
| guinea pig | LDLo | intravenous | 240ug/kg (0.24mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 251, 1965. |
| mammal (species unspecified) | LDLo | intravenous | 526ug/kg (0.526mg/kg) | Acta Pharmaceutica Jugoslavica. Vol. 24, Pg. 179, 1974. | |
| mouse | LD50 | intracrebral | 63ug/kg (0.063mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961. |
| mouse | LD50 | intravenous | 330ug/kg (0.33mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(2), Pg. 224, 1982. | |
| rabbit | LDLo | intravenous | 110ug/kg (0.11mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 329, 1937. |
K-Strophanthidine Safety Profile
Hazard Codes: 
T+ Very toxic.
Risk Statements: 26/27/28
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-45
S22: Do not breathe dust.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
RIDADR: UN 2811 6.1/PG 1
WGK: Germany 3
RTECS: FH5425000
A deadly poison by intravenous routes.
K-Strophanthidine Specification
K-Strophanthidine (66-28-4),which also can be called for K-Strophanthidin ; Cymarigenen ; 5Beta,20[22]-cardenolide-19-one-3beta,5,14-triol ; 3Beta,5,14-trihydroxy-19-oxo-5beta,20[22]-cardenolide ; Strophanthidin k ; Strophanthidin ; 19-Oxo-cardogenen-(20:22)-triol-(3-beta,5,14) ; 3,5,14-Trihydroxy-19-oxo-,(3-beta,5-beta)-card-20(22)-enolid .The appropriate storage temperature of K-Strophanthidine (66-28-4) is -20℃.
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