Angewandte
Chemie
The unsymmetrical compounds 5–7 were probed by
2D NMR spectroscopy. Figure 5 shows a section of the
ROESY spectra of [D8]toluene (a) and [D4]methanol (b)
solutions of 5. In [D8]toluene, the CH3 signal of the cysteine S-
tert-butyl group (1.2 ppm) is connected with the phenyl CH
protons (7.2–7.1 ppm) of the O-benzyl group of the serine
helical nanotubes. These compounds represent a major
advance in this field, not only through their synthesis and
formation independent of the amino acid sidechains, but also
by being versatile in their room for structural variation and
side chain decoration on the surface in a manner reminiscent
of phage display. Currently we are investigating possible
applications for these new materials.
Received: August 16, 2006
Published online: November 7, 2006
Keywords: helical structures · nanotubes · polymers ·
.
self-assembly· supramolecular chemistry
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Figure 5. Section of the ROESY spectra of [D8]toluene (a) and
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spectra of 6 and 7 in [D6]acetone and [D4]methanol, respec-
tively (see the Supporting Information).
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