Journal of Carbohydrate Chemistry p. 205 - 219 (2017)
Update date:2022-08-10
Topics:
Zhou, Zhifang
Ding, Wenzhang
Li, Chen
Wu, Zhimeng
A repeat unit of cell wall teichoic acids (WTA) isolated from E. faecium U0317 was chemically synthesized efficiently by a stepwise strategy. It was derivatized with a 5-aminopentanyl linker to facilitate conjugation with carrier proteins KLH and HSA. Immunological studies of the KLH conjugate 1 demonstrated that it could provoke robust immune responses and high titers of IgG antibodies, which could successfully recognize the synthesized WTA repeat unit 3. This result suggested that synthetic glycoconjugate 1 could be a promising vaccine candidate against E. faecium for further studies.
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Doi:10.1246/bcsj.59.235
(1986)Doi:10.1021/jp0670687
(2007)Doi:10.1080/10286020.2012.680440
(2012)Doi:10.1016/j.tetlet.2007.08.121
(2007)Doi:10.1007/BF00575188
(1983)Doi:10.1016/j.cclet.2016.02.015
(2016)