10.1002/cctc.201701408
ChemCatChem
COMMUNICATION
binding of substrates. However, further experiments are required
to prove whether these enzymes are capable of catalysing imine
formation, and thus be confidently classified as RedAms.
Acknowledgements
S.P.F. acknowledges a CASE award from the UK Biotechnology
and Biological Sciences Research Council (BBSRC) and Pfizer.
J.M.S was funded by grant BB/M006832/1 from the BBSRC and
S.L.M. was supported by a CASE studentship from Johnson
Matthey. NJT is grateful to the ERC for an Advanced Grant.
AspRedAm
Pfizer IR48
Pfizer IR91
a)
D171
D169
S97
S95
T209
N93
Experimental Section
See supporting information.
Y172
M210
Keywords: biocatalysis • imine reductase • reductive amination
• amines • chirality
W210
W179
NADPH
Y177
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