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M. Glaser et al.
vs DMSO for the preparation of 18F-FBA. The crude reaction
mixture of 18F-SFB was transferred onto an SPE cartridge
(SepPak ‘Plus Silica’, Waters WAT020520) that had been
conditioned with ethyl acetate (10 mL) and n-hexane (10 mL)
and dried with a stream of nitrogen (100 mL/min) for 2 min. The
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¨
¨
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In summary, a novel two-step radiosynthesis of the acylation
reagent 18F-SFB has been established. The intermediate 18F-FBA
was produced in high radiochemical yields by an improved
procedure using microwave heating. In contrast to previously
published protocols, the new synthesis of 18F-SFB is purely
based on non-aqueous chemistry. This is potentially beneficial in
terms of synthesis simplification and time saving for conjugation
reactions. The reaction volume of 18F-SFB can readily be
adjusted by evaporation, both for subsequent aqueous or
non-aqueous coupling reactions. The new method has also the
potential to become automated.
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