Journal of labelled compounds and radiopharmaceuticals p. 449 - 461 (2000)
Update date:2022-07-30
Topics:
Mitulovi, Goran
Laemmerhofer, Michael
Maier
Lindner, Wolfgang
A procedure for the synthesis of (R)- and (S)-enantiomers of α-carbon deuterium-labelled α-amino acids, exemplified for (R)- and (S)-[2-2H1]-Leu is described. Starting from the respective (S)- or (R)-enantiomer or from the racemic mixture of an α-amino acid the selective proton exchange at the α-carbon is carried out by racemization via a Schiff base in monodeuterated acetic acid as solvent which serves as deuterium source. After N-protection the racemic mixture is liquid chromatographically separated into the individual (R)- and (S)-enantiomers on preparative scale employing a chiral anion exchanger based on carbamoylated quinine as chiral selector. After deprotection the enantiomerically pure products can be obtained in good yields.
View Moreshandong zhongke taidou chemical co.,ltd
Contact:86-531-88682301
Address:Jinan shandong Province CHina
website:http://www.simagchem.com
Contact:+86-592-2680277
Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Contact:0792-8228321
Address:10TH Floor No.121 binjiang Road Xunyang District
website:http://www.NEM.COM.CN
Contact:+86-393-4411771
Address:The west section of shengli Road,Puyang,Henan Province,China
Yancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Doi:10.1039/P29790001011
(1979)Doi:10.1039/a701851g
(1997)Doi:10.1002/anie.201807881
(2018)Doi:10.1007/BF00950990
()Doi:10.1021/ja00308a028
(1985)Doi:10.1039/c39830000348
(1983)