Heterocycles p. 1575 - 1582 (2012)
Update date:2022-08-15
Topics:
Thacker, Nathan C.
Molnar-Toth, Judit
Miska, Judy L.
Barletta, Raul G.
Takacs, James M.
D-Cycloserine (DCS), a second stage drug for the treatment of tuberculosis, is synthesized in 19.8% overall yield from DL-serine methyl ester. This synthetic route gives both enantiomers of cycloserine via a corrected and improved one pot resolution procedure using D- and L-tartaric acids. The route is used to synthesize a 13C-labeled derivative for use in biological studies.
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