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Scheme 2 A possible mechanism.
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mediate C takes place to yield the desired product and
regenerate the active Pd(0) species. The present results support
the former pathway in terms of the selectivity of entry 2 in
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´
rez and
´
´
´
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3484.
In summary, we have developed a mild method for the
synthesis of 6H-benzo[c]chromenes by palladium-catalyzed
annulations of 2-(2-iodophenoxy)-1-arylethanones and 1-(2-
iodophenoxy)propan-2-one with arynes. This new route
allows formation of two carbon–carbon bonds in one-pot
through an sp3 carbon functionalization process. Importantly,
we provide a convenient approach to the important class of
6H-benzo[c]chromenes. Work to extend the reaction and study
the detailed mechanism is currently underway.
This research was supported by the Scientific Research
Fund of Hunan Provincial Education Department (Nos.
08B053 and 08A037) and NNSFC (No. 20872112).
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c
This journal is The Royal Society of Chemistry 2010
Chem. Commun., 2010, 46, 8183–8185 8185