Journal of Medicinal Chemistry p. 11039 - 11049 (2016)
Update date:2022-08-04
Topics:
Debenham, John S.
Madsen-Duggan, Christina
Clements, Matthew J.
Walsh, Thomas F.
Kuethe, Jeffrey T.
Reibarkh, Mikhail
Salowe, Scott P.
Sonatore, Lisa M.
Hajdu, Richard
Milligan, James A.
Visco, Denise M.
Zhou, Dan
Lingham, Russell B.
Stickens, Dominique
Demartino, Julie A.
Tong, Xinchun
Wolff, Michael
Pang, Jianmei
Miller, Randy R.
Sherer, Edward C.
Hale, Jeffrey J.
The discovery of novel 4-hydroxy-2-(heterocyclic)pyrimidine-5-carboxamide inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described. These are potent, selective, orally bioavailable across several species, and active in stimulati
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