Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Diatrizoate sodium |
EINECS | 212-004-1 |
CAS No. | 737-31-5 | Density | N/A |
PSA | 98.33000 | LogP | 1.92670 |
Solubility | H2O: 0.35 g/mL, slightly turbid, colorless | Melting Point |
261-262° (dec) |
Formula | C11H9 I3 N2 O4 . Na | Boiling Point | 614.1 °C at 760 mmHg |
Molecular Weight | 635.899 | Flash Point | 325.2 °C |
Transport Information | N/A | Appearance | N/A |
Safety | 36 | Risk Codes | 42/43 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
Benzoicacid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt (9CI); Benzoic acid,3,5-diacetamido-2,4,6-triiodo-, monosodium salt (8CI); Benzoic acid,3,5-diacetamido-2,4,6-triiodo-, sodium salt (6CI);3,5-Diacetamido-2,4,6-triiodobenzoic acid sodium salt; Diatrizoate sodium;Hypaque; Hypaque 50; Hypaque sodium; Radioselectan; Sodium3,5-diacetamido-2,4,6-triiodobenzoate; Sodium amidotrizoate; Sodiumdiatrizoate; Triombrin; Triombrine; Urografic acid sodium salt; Urografin S;Urographing 370; Urovist 300 |
Article Data | 2 |
Conditions | Yield |
---|---|
With sodium carbonate In water |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide | 76% |
In N,N-dimethyl-formamide | 76% |
In N,N-dimethyl-formamide | 76% |
In N,N-dimethyl-formamide for 6h; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 12h; | 41% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 18 - 25℃; | 10% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide |
sodium diatrizoate
Propanedioic acid, [[3,5-bis(acetylamino)-2,4,6-triiodobenzoyl]oxy]methyl-bis(1-methylethyl)ester
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol | 255 g (51%) |
Conditions | Yield |
---|---|
With ammonium hydroxide In N,N-dimethyl-formamide | 121 g (66%) |
With ammonium hydroxide In N,N-dimethyl-formamide | 121 g (66%) |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide | |
In water; N,N-dimethyl-formamide |
sodium diatrizoate
Conditions | Yield |
---|---|
With hydrogen at 21℃; Mechanism; Reagent/catalyst; Concentration; |
Conditions | Yield |
---|---|
With hydrogenchloride In water for 6h; Reflux; | |
With hydrogenchloride In water for 6h; Reflux; |
IUPAC Name: Sodium 3,5-diacetamido-2,4,6-triiodobenzoate
Synonyms of Sodium amidotrizoate (CAS NO.737-31-5): Sodium amidotrizoate ; 3,5-Diacetamido-2,4,6-triiodobenzoic acid sodium salt
Molecular Structure :
Molecular Formula :C11H8I3N2NaO4
Molecular Weight : 635.90
CAS NO:737-31-5
H bond acceptors: 6
H bond donors: 3
Freely Rotating Bonds: 3
Polar Surface Area: 77.92 Å2
EINECS : 212-004-1
Mol File: 737-31-5.mol
Flash Point: 325.2 °C
Enthalpy of Vaporization: 95.8 kJ/mol
Boiling Point: 614.1 °C at 760 mmHg
Vapour Pressure: 6.19E-16 mmHg at 25°C
Solubility : H2O: 0.35 g/mL, slightly turbid, colorless
Product Categories of of Sodium amidotrizoate (CAS NO.737-31-5): Organics
SMILES: [Na+].Ic1c(c(I)c(c(I)c1NC(=O)C)C([O-])=O)NC(=O)C
InChI: InChI=1/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1
InChIKey: ZEYOIOAKZLALAP-REWHXWOFAW
Std. InChI: InChI=1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1
Std. InChIKey: ZEYOIOAKZLALAP-UHFFFAOYSA-M
Sodium amidotrizoate (CAS NO.737-31-5) is used as water-soluble contrast agent, excreted from the urine after intravenous administration. it is also commonly used in imaging of urinary tract, renal pelvis, cardiovascular and cerebral angiography.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intravenous | 11300mg/kg (11300mg/kg) | Compilation of LD50 Values of New Drugs. | |
dog | LD50 | intravenous | 13200mg/kg (13200mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956. |
mouse | LD50 | intramuscular | 20349mg/kg (20349mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 307, 1956. | |
mouse | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994. |
mouse | LD50 | intravenous | 14gm/kg (14000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956. | |
mouse | LD50 | oral | > 7gm/kg (7000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994. |
rabbit | LD50 | intravenous | 12200mg/kg (12200mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956. | |
rat | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994. |
rat | LD50 | intravenous | 11400mg/kg (11400mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956. | |
rat | LD50 | oral | > 7gm/kg (7000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994. |
Hazard Codes: Xn
Risk Statements: 42/43
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 36
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: DG6125000
F: 8-10
Consumption usage of Sodium amidotrizoate (CAS NO.737-31-5):
1. Retrograde pyelography: 20% 6 ~ 10ml. 2. Urography: 50% 20 ~ 30ml. 3. Cerebral angiography: 45% or less solution of 10ml. 4. Heart and great vessel angiography: 50% 40ml.
Note: Sodium amidotrizoate may cause nausea, vomiting, salivation, dizziness, urticaria and other reactions. It is banned to serious liver and kidney dysfunction, active tuberculosis, hyperthyroidism, and allergic to iodine. The adrenaline is available when allergic reactions and hypotension happen.