88224-05-9 Usage
General Description
L-Isoleucine allyl ester p-toluenesulfonate salt is an organic compound that is a derivative of the naturally occurring amino acid, isoleucine. This chemical compound is synthesized by esterification of L-isoleucine with an allyl group and is further treated with p-toluenesulfonic acid to form the salt. In its isolated form, it appears as a white or off-white crystalline solid. It is used in various chemical reactions due to its ability to act as a reactant or catalyst. Further, it can also be used in research related to biochemistry and pharmaceuticals. Its toxicity and safety measures are not extensively studied, hence should be handled with standard laboratory precautions.
Check Digit Verification of cas no
The CAS Registry Mumber 88224-05-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,2,2 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 88224-05:
(7*8)+(6*8)+(5*2)+(4*2)+(3*4)+(2*0)+(1*5)=139
139 % 10 = 9
So 88224-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H17NO2.C7H8O3S/c1-4-6-12-9(11)8(10)7(3)5-2;1-6-2-4-7(5-3-6)11(8,9)10/h4,7-8H,1,5-6,10H2,2-3H3;2-5H,1H3,(H,8,9,10)/t7-,8-;/m0./s1
88224-05-9Relevant articles and documents
Allyl Esters as Selectively Removable Carboxy-protecting Functions in Peptide and N-Glycopeptide Syntheses
Waldmann, Herbert,Kunz, Horst
, p. 1712 - 1725 (2007/10/02)
Allyl esters are advantageous in protection of the carboxylic function in peptide and glycopeptide syntheses and can easily be synthesized from amino acids.They are stable under acidic conditions used for the removal of the Boc and Z groups.Under neutral or weakly basic conditions allyl esters are cleaved smoothly on treatment with catalytic amounts of tris(triphenylphosphane)rhodium(I) chloride in ethanol/water (9:1) leaving the N-protecting function and the N-glycosidic bond untouched.Selective deblocking of the α-carboxylic function of protected N-glycosylated asparagine derivatives 15 carried out in this way is exploited in C-terminal chain extension in the synthesis of N-glycotripeptides 17,e.g 17c, the latter representing a partial sequence of a human immunoglobulin G1.