82294-70-0

Basic information

• Product Name: 4-Methylthiazole-5-carboxaldehyde
• Synonyms: FMT;IFLAB-BB F2124-0219;4-METHYL-5-THIAZOLECARBOXALDEHYDE;4-METHYL-5-FORMYLTHIAZOLE;4-METHYL-5-THIAZOLYL ALDEHYDE;4-METHYLTHIAZOLE-5-ALDEHYDE;4-METHYL-THIAZOLE-5-CARBALDEHYDE;4-METHYLTHIAZOLE-5-CARBOXALDEHYDE
• CAS NO: 82294-70-0
• Molecular Formula: C₅H₅NOS
• Molecular Weight: 127.16
• EINECS: 1308068-626-2
• Product Categories: ALDEHYDE;Aldehydes;Thiazoles, Isothiazoles &Benzothiazoles;heterocyclic/Aliphatic series;Thiazoles, Isothiazoles & Benzothiazoles;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 82294-70-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 74-78 °C(lit.)
• Boiling Point: 118°C/21mmHg(lit.)
• Flash Point: 91.8 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.0747mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.53±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 4-Methylthiazole-5-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylthiazole-5-carboxaldehyde(82294-70-0)
• EPA Substance Registry System: 4-Methylthiazole-5-carboxaldehyde(82294-70-0)

Safety Data

• Hazard Codes: Xi
• Statements: 41-43
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 82294-70-0(Hazardous Substances Data)

Usage

Uses

4-Methylthiazole-5-carboxaldehyde is used as pharmaceutical intermediate.

InChI:InChI=1/C5H5NOS/c1-4-5(2-7)8-3-6-4/h2-3H,1H3

Upstream product

• 408526-37-4 4-methylthiazole-5-carbonitrile 
• 103987-43-5 N-benzenesulfonyl-N'-(4-methyl-thiazole-5-carbonyl)-hydrazine 
• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 20582-55-2 ethyl 4-methylthiazole-5-carboxylate 
• 1977-06-6 (4-methyl-1,3-thiazol-5-yl)methanol 
• 3581-91-7 4,5-Dimethylthiazole 
• 181424-10-2 5-bromomethyl-4-methyl-thiazole 
• 81569-44-0 methyl 4-methyl thiazole-5-carboxylate 
• 89179-72-6 4-methyl-thiazole-5-carboxylic acid hydrazide 
• 860182-30-5 4-methyl-thiazole-5-carboxylic acid dipropylamide 
• 13750-63-5 (4-methylthiazol-2-yl)-methanol 
• 79-37-8 oxalyl dichloride 
• 54237-09-1 4-methylthiazole-5-carboxylic acid chloride 
• 20485-41-0 4-methylthiazole-5-carboxylic acid 

Downstream Products

• 1977-06-6 (4-methyl-1,3-thiazol-5-yl)methanol 
• 112953-21-6 Diphenylmethyl (6R,7R)-3-<(Z)-2-(4-Methyl-1,3-thiazol-5-yl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 135299-73-9 Diphenylmethyl (6R,7R)-3-<(E)-2-(4-Methyl-1,3-thiazol-5-yl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 138514-31-5 7-phenylacetamido-3-[(Z)-2-(4-methyl-5-thiazolyl)ethenyl]-4-aminocephalosporanic acid p-methoxybenzylester 
• 104146-11-4 p-Methoxybenzyl 7-phenylacetamido-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 247216-73-5 (E)-5-(N-benzylformimidoyl)-4-methylthiazole 
• 117467-28-4 cefditoren pivoxil 
• 138514-32-6 Pivaloyloxymethyl 7-<(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 138450-73-4 p-Methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 104146-13-6 p-Methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido>-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 104146-53-4 7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt 
• 119608-99-0 p-Methoxybenzyl 7-amino-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 104146-12-5 p-Methoxybenzyl 7-amino-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 181424-10-2 5-bromomethyl-4-methyl-thiazole 

Relevant articles and documents

Synthesis method of 4-methylthiazole-5-formaldehyde

The invention provides a synthesis method of 4-methylthiazole-5-formaldehyde. The method comprises the following steps: 1) dissolving 4-methylthiazole-5-ethanol in a solvent, and carrying out oxidation reaction in the presence of a catalyst to obtain 4-methylthiazole-5-acetic acid; and 2) carrying out heating reaction on the 4-methylthiazole-5-acetic acid obtained in the step 1) in the presence of oxygen and a metal salt catalyst to obtain the 4-methylthiazole-5-formaldehyde. According to the method, 4-methylthiazole-5-ethanol is used as a raw material, the raw material is green, cheap and easy to obtain, the reaction process is mild in condition and environmentally friendly, the result selectivity is good, the yield is high, good economic benefits are achieved, and the method is suitable for industrial production.

Dimethyl sulfoxide-accelerated reductive deamination of aromatic amines with t-BuONO in tetrahydrofuran

An efficient method for the conversion of aryl amines into arenes by a one-pot reductive deamination has been achieved. It was found the reductive deamination using t-BuONO in tetrahydrofuran could be accelerated by dimethyl sulfoxide and provided the deamination products with good yields under mild conditions. A plausible mechanism is discussed.

HETEROARYL COMPOUNDS AS PDE10A INHIBITORS

The present invention provides heteroaryl compounds as Phosphodiesterase 10A (PDE I OA) inhibitors. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders by inhibiting Phosphodiesterase 10A enzyme. Also provided herein are processes for preparing compounds described herein, Formula (I), intermediates used in their synthesis, pharmaceutical compositions thereof.