78658-49-8Relevant articles and documents
Application of the thioacid-azide ligation (TAL) for the preparation of glycosylated and fluorescently labeled amino acids
Rohmer, Katja,Mannuthodikayil, Jamsad,Wittmann, Valentin
, p. 437 - 446 (2015)
The reaction of thiocarboxylic acids with azides (thioacid-azide ligation, TAL) is a chemoselective transformation, leading to the formation of amide bonds. Especially in the case of electron-deficient sulfonyl azides, the reaction occurs in excellent yie
Convenient synthesis of L-proline benzyl ester
Cordova, Armando,Reed, Neal N.,Ashley, Jon A.,Janda, Kim D.
, p. 3119 - 3122 (2007/10/03)
Mesylates or tosylates of δ-hydroxy-L-norvaline esters spontaneously afford L-proline esters upon exposure to aqueous buffer in near quantitative yield. This novel reaction has led to the development of a simple route to optically active proline esters.
Synthesis of the Major Component of Alamethicin
Gisin, B.F.,Davis, D.G.,Borowska, Z.K.,Hall, J.E.,Kobayashi, S.
, p. 6373 - 6377 (2007/10/02)
Alamethicin (ALA), a natural membrane-active antibiotic, consists of several components.The major component, ALA I, was isolated in pure form and compared with the synthetic peptide acetyl-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phol obtained by stepwise segment condensation on a polystyrene support.The synthetic and natural products appeared essentially identical by amino acid analysis, high performance liquid chromatography, 600-MHz proton nuclear magnetic resonance spectroscopy, mass spectrometry, electrical activity in lipid bilayer membranes, and antimicrobial activity.It is concluded that ALA I has the structure indicated above.