75853-18-8

Basic information

• Product Name: 2,3-Difluorobenzyl alcohol
• Synonyms: 2,3-DIFLUOROBENZYL ALCOHOL;2,3-Difluorobenzyl alcohol 98%;2,3-Difluorobenzylalcohol98%;2,3-Difluorophenyl alcohol;2,3-Difluorobenzyl alcohol,94%;2,3-difluorobenzyl alcohol / 2,3-difluorobenzyl alcohol;2,3-difluoro-Benzenemethanol;(2,3-Difluorophenyl)methanol
• CAS NO: 75853-18-8
• Molecular Formula: C₇H₆F₂O
• Molecular Weight: 144.12
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Aromatic compound;Miscellaneous;Alcohols;C7 to C8;Oxygen Compounds;Fluorine series
• Mol File: 75853-18-8.mol

Chemical Properties

• Boiling Point: 101.45°C (rough estimate)
• Flash Point: 201 °F
• Appearance: Clear colorless to pale brown/Liquid
• Density: 1.282 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.265mmHg at 25°C
• Refractive Index: n20/D 1.492(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.61±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 7089243
• CAS DataBase Reference: 2,3-Difluorobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluorobenzyl alcohol(75853-18-8)
• EPA Substance Registry System: 2,3-Difluorobenzyl alcohol(75853-18-8)

Safety Data

• Hazard Codes: Xi
• Statements: 41-36/37/38
• Safety Statements: 26-39-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 75853-18-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2,3-Difluorobenzyl alcohol is used as an intermediate in the chemical synthesis of various organic compounds. Its unique structure with fluorine atoms allows for the creation of a wide range of products with different applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-difluorobenzyl alcohol is used as a building block for the synthesis of new drugs and drug candidates. Its fluorinated structure can impart specific properties to the final drug molecule, such as increased metabolic stability or improved binding affinity to target proteins.
Used in Agrochemical Industry:
2,3-Difluorobenzyl alcohol can be employed in the agrochemical industry for the development of new pesticides and herbicides. The incorporation of fluorine atoms into the molecule can enhance the biological activity and selectivity of these compounds, leading to more effective and environmentally friendly products.
Used in Material Science:
In the field of material science, 2,3-difluorobenzyl alcohol can be used to develop new materials with specific properties. For example, its fluorinated structure can be utilized to create self-assembled monolayers or thin films with unique surface properties, such as increased hydrophobicity or reduced friction.
Used in Chemical Research:
2,3-Difluorobenzyl alcohol is also used in chemical research as a model compound to study various reaction mechanisms and to develop new synthetic methodologies. Its unique structure allows researchers to explore the effects of fluorine substitution on the reactivity and selectivity of different chemical reactions.
For example, the provided materials mention the use of 2,3-difluorobenzyl alcohol in the production of 1-bromomethyl-2,3-difluoro-benzene using reagent PBr3 and solvent toluene at a temperature of 100°C for 1 hour. This application demonstrates the utility of 2,3-difluorobenzyl alcohol in chemical synthesis studies, where it serves as a starting material for the preparation of other organic compounds with potential applications in various industries.

InChI:InChI=1/C7H6F2O/c8-6-3-1-2-5(4-10)7(6)9/h1-3,10H,4H2

Upstream product

• 4519-39-5 2,3-difluorobenzoic acid 
• 367-11-3 ortho-difluorobenzene 

Downstream Products

• 113211-94-2 2,3-difluorobenzyl bromide 
• 367488-46-8 (2,3-difluorobenzyl) 2,2,2-trichloroacetimidate 
• 367488-51-5 (3R,3aR,6R,6aR)-3,6-Bis-(2,3-difluoro-benzyloxy)-tetrahydro-furo[3,2-b]furan-2,5-dione 
• 130305-15-6 2,3-difluorobenzyl acetate 
• 1209012-72-5 methyl (2,3-difluorobenzyl 5-acetamido-4,7,8-tri-O-acetyl-9-azido-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)-onate 
• 1209012-91-8 methyl ((2,3-difluorobenzyl) 5-fluoroacetamido-4,7,8-tri-O-acetyl-9-azido-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 1209012-92-9 methyl ((2,3-difluorobenzyl) 5-chloroacetamido-4,7,8-tri-O-acetyl-9-azido-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 1209012-93-0 methyl ((2,3-difluorobenzyl) 5-(o-nitrotoluenesulfonamido)-4,7,8-tri-O-acetyl-9-azido-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 

Relevant articles and documents

Dibenzo seven-membered ring derivative as well as preparation method and application thereof

The invention relates to a dibenzo seven-membered ring derivative as well as a preparation method and application thereof. The chemical structure of the dibenzo seven-membered ring derivative is shownas a formula (I), and X1 and X2 are respectively and independently selected from H, F, Cl, Br or I. The preparation method has easily available raw materials, and can ensure continuous supply and production; the raw materials are cheap and have the cost advantage; and thiophenol or sodium thiophenol is not used, so that the method is more environment-friendly and is also beneficial to the body health of related personnel. 7,8-difluorodibenzo[b,e]thiazepine-11(6H)-one as one of the products can further react to obtain 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol, and the 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol can be used as an important intermediate for preparing a drug baloxavir, so that baloxavir preparation cost is reduced.

9-(2-fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents

Several substituted aryl and 6-alkylamino analogues of the anticonvulsant purine 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Derivatives with a second fluoro substituent in the 5- or 6-position of the aryl moiety were very active with ip ED50's that ranged from 2 to 4 mg/kg. Congeners in which the purine 6-substituent was varied among a number of alkylamino groups possessed potent activity against MES that was comparable to or several times better than phenytoin.