75679-58-2

Basic information

• Product Name: 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
• Synonyms: 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
• CAS NO: 75679-58-2
• Molecular Formula: C₁₇H₁₈O₅
• Molecular Weight: 302.32182
• Mol File: 75679-58-2.mol

Chemical Properties

• Melting Point: 169-170 °C(Solv: dichloromethane (75-09-2); methanol (67-56-1))
• Boiling Point: 503.5°Cat760mmHg
• Flash Point: 184.7°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 9.24E-11mmHg at 25°C
• Refractive Index: 1.594
• PKA: 7.31±0.40(Predicted)
• CAS DataBase Reference: 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone(75679-58-2)
• EPA Substance Registry System: 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone(75679-58-2)

Safety Data

• Hazardous Substances Data: 75679-58-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is used as a pharmaceutical agent for its potential health benefits, including its antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties. It may help improve cardiovascular health and reduce the risk of various chronic diseases.
Used in Nutraceutical Industry:
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is used as a nutraceutical ingredient for its potential health-promoting properties, including its antioxidant and anti-inflammatory effects. It may be incorporated into dietary supplements and functional foods to support overall health and well-being.
Used in Cosmetic Industry:
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is used as an active ingredient in cosmetic products for its antioxidant and anti-inflammatory properties. It may help protect the skin from environmental stressors and support skin health and appearance.
Used in Research:
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is used as a research compound to further investigate its potential health benefits and mechanisms of action. Further research is needed to fully understand its potential applications and to develop new therapeutic strategies based on its properties.

InChI:InChI=1/C17H18O5/c1-21-13-6-3-11(4-7-13)5-8-14(19)17-15(20)9-12(18)10-16(17)22-2/h3-4,6-7,9-10,18,20H,5,8H2,1-2H3

Upstream product

• 56121-44-9 (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 2174-64-3 5-methoxyresorcinol 
• 22442-48-4 3-(4-methoxyphenyl)propionitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 3602-54-8 4,6-dihydroxy-2-methoxyacetophenone 
• 855740-21-5 2′,4′-dihydroxy-4,6′-dimethoxychalcone 
• 84457-62-5 2'-hydroxy-4'-benzyloxy-4,6'-dimethoxychalkone 
• 39548-89-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 

Downstream Products

• 75679-63-9 2',4'-diacetoxy-4,6'-dimethoxydihydrochalkone 
• 3791-75-1 2'-hydroxy-4,4',6'-trimethoxydihydrochalcone 
• 75679-64-0 2'-acetoxy-4,4',6'-trimethoxydihydrochalkone 

Relevant articles and documents

Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Specialized pro-resolving mediators (SPMs) comprise lipid mediators (LMs) produced from polyunsaturated fatty acids (PUFAs) via stereoselective oxygenation particularly involving 12/15-lipoxygenases (LOXs). In contrast to pro-inflammatory LMs such as leuk

Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction

Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.

COMPOUNDS, THEIR SYNTHESES, AND THEIR USES

Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones

Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identification of analogues with selective and significant in vitro anti-Trypanosoma cruzi activity. Further SAR studies were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted in the discovery of 2′,4′-diallyloxy- 6′-methoxy chalcones with improved selectivity against this parasite at concentrations below 25 μM, four of which exhibited a selectivity index greater than 12.

Syntheses of Two New Naturally Occurring Dihydrochalkones, Uvangolatin and 2',4'-Dihydroxy-4,6'-dimethoxydihydrochalkone

The structures proposed for the two naturally occurring dihydrochalkones, uvangolatin isolated from Uvaria angolensis as 2',4'-dihydroxy-6'-methoxydihydrochalkone (I) and another dihydrochalkone isolated from Iryanthera laevis as 2',4'-dihydroxy-4,6'-dime