75091-92-8

Basic information

• Product Name: cis-4-(Trifluoromethyl)cyclohexanol
• Synonyms: cis-4-(Trifluoromethyl)cyclohexanol;Cyclohexanol, 4-(trifluoroMethyl)-, cis-;cis-4-(Trifluoromethyl)cyclohexan-1-ol
• CAS NO: 75091-92-8
• Molecular Formula: C₇H₁₁F₃O
• Molecular Weight: 168.1568496
• Mol File: 75091-92-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 160.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.231±0.06 g/cm3(Predicted)
• PKA: 14.88±0.40(Predicted)
• CAS DataBase Reference: cis-4-(Trifluoromethyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4-(Trifluoromethyl)cyclohexanol(75091-92-8)
• EPA Substance Registry System: cis-4-(Trifluoromethyl)cyclohexanol(75091-92-8)

Safety Data

• Hazardous Substances Data: 75091-92-8(Hazardous Substances Data)

Usage

General Description

"Cis-4-(Trifluoromethyl)cyclohexanol" is a chemical compound with a molecular formula of C7H11F3O. It is characterized by a cyclohexane ring with a trifluoromethyl group and a hydroxyl group attached to it. cis-4-(Trifluoromethyl)cyclohexanol is used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and fine chemicals. It is also used as a chiral building block in the synthesis of chiral ligands and catalysts. Cis-4-(Trifluoromethyl)cyclohexanol has been reported to exhibit insecticidal and acaricidal activities, making it potentially useful in agricultural applications. Additionally, it is a valuable intermediate in the production of flavors and fragrances.

Upstream product

• 401-75-2 trifluoromethylcyclohexane 
• 402-45-9 4-hydroxybenzotrifluoride 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 343217-50-5 Trifluoro-acetic acid 4-trifluoromethyl-cyclohexyl ester 

Downstream Products

• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 30129-21-6 7,7,7-Trifluormenthan-8-ol 
• 1355615-80-3 C₂₀H₂₆F₃N₅O₄ 

Relevant articles and documents

Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization

Reported here is a straightforward process in which a cyclic (alkyl)(amino)carbene/Rh catalyst system facilitates the preferential addition of hydrogen to the substitution sites of difluoromethylated and trifluoromethylated arenes and heteroarenes, leading to dearomative reduction. This strategy enables the diastereoselective synthesis of cis-difluoromethylated and cis-trifluoromethylated cycloalkanes and saturated heterocycles, and even allows formation of all-cis multi-trifluoromethylated cyclic products with a defined equatorial orientation of the di- and trifluoromethyl groups. Deuterium-labeling studies indicate that hydrogen preferentially attacks the substitution sites of planar arenes, resulting in dearomatization, possibly with heterogeneous Rh as the reactive species, followed by either reversible or irreversible hydrogen addition to the nonsubstitution sites.

Hydrogen-free ring hydrogenation of phenol to cyclohexanol over a rhodium-loaded titanium(IV) oxide photocatalyst

Since photocatalytic reactions are almost consistent with the concept of green chemistry, substance conversion using photocatalysts has recently attracted the attention of researchers in the fields of organic chemistry, physical chemistry and material chemistry. We investigated photoinduced ring hydrogenation of phenol over a metal-loaded titanium(IV) oxide (TiO2) photocatalyst without the use of H2 gas and we report here the effects of various parameters, including the type and amount of metal co-catalyst loaded on TiO2 and the kinds of solvents and hole scavengers, on the ring hydrogenation. We found that the combination of an Rh co-catalyst, water and oxalic acid resulted in the highest yield of cyclohexanol. Detailed analyses revealed that phenol was first hydrogenated to cyclohexanone via keto-enol tautomerism of cyclohexenol followed by hydrogenation of cyclohexanone to cyclohexanol and that adsorption of phenol onto Rh-TiO2 is a factor of great importance for the ring hydrogenation.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.