700376-57-4 Usage
Description
Lcis4,5methanoprolinamide HCl, also known as (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide, is an organic compound that serves as an intermediate in the synthesis of dipeptidyl peptidase IV (DDP-IV) inhibitors. These inhibitors have potential applications in the treatment of diabetes.
Uses
Used in Pharmaceutical Industry:
Lcis4,5methanoprolinamide HCl is used as an intermediate for the synthesis of DDP-IV inhibitors for the development of potential antidiabetes agents. These inhibitors play a crucial role in regulating glucose levels in the body, making them valuable in the treatment and management of diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 700376-57-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,0,3,7 and 6 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 700376-57:
(8*7)+(7*0)+(6*0)+(5*3)+(4*7)+(3*6)+(2*5)+(1*7)=134
134 % 10 = 4
So 700376-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N2O/c7-6(9)5-2-3-1-4(3)8-5/h3-5,8H,1-2H2,(H2,7,9)/t3-,4-,5+/m1/s1
700376-57-4Relevant articles and documents
Method for preparing epimer of saxagliptin heterocyclic intermediate
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Paragraph 0010; 0028-0031; 0032-0035; 0036-0039; 0040-0043, (2021/07/01)
The invention discloses a method for preparing an epimer (1S, 3R, 5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide of a saxagliptin heterocyclic intermediate and a salt thereof The method comprises the following steps: racemizing (1S, 3S, 5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide or the salt thereof under an alkaline condition, protecting by Boc, purifying, and removing a protecting group to form a salt, thereby obtaining the target product. Compared with the prior art, the method for preparing the epimer (1S, 3R, 5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide of the saxagliptin heterocyclic intermediate and the salt thereof, disclosed by the invention, has the advantages of simple operation and high yield, and is suitable for industrial production.
