64187-48-0

Basic information

• Product Name: Z-HYP-OME
• Synonyms: N-Cbz-trans-4-hydroxy-L-proline methyl ester;Z-O-tert-Butyl-L-4-hydroxyproline;(2S,4R)-1-(Benzyloxycarbonyl)-2-(methoxycarbonyl)-4-hydroxypyrrolidine;(2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester;1-Benzyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;N-(Benzyloxycarbonyl)-4-hydroxyproline methyl ester;(2S,4R)-1-benzyl 2-Methyl 4-hydro×ypyrrolidine-1,2-dicarbo×ylate;N-Benzyloxycarbonyl-4-trans-hydroxy-L-proline Methyl ester, 98%
• CAS NO: 64187-48-0
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.29
• EINECS: 236-831-2
• Mol File: 64187-48-0.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 422.779 °C at 760 mmHg
• Flash Point: 209.49 °C
• Appearance: Pale yellow/viscous liquid
• Density: 1.313
• Vapor Pressure: 6.67E-08mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: −20°C
• PKA: 14.25±0.40(Predicted)
• CAS DataBase Reference: Z-HYP-OME(CAS DataBase Reference)
• NIST Chemistry Reference: Z-HYP-OME(64187-48-0)
• EPA Substance Registry System: Z-HYP-OME(64187-48-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 64187-48-0(Hazardous Substances Data)

Usage

Uses

N-(Benzyloxycarbonyl)-4-hydroxyproline Methyl Ester, can be used as an intermediate in the synthesis of various pharmaceutical and biologically active compounds. It is used in the synthesis of Doripenem (D534800), an Antibacterial agent.

InChI:InChI=1/C14H17NO5/c1-19-13(17)12-7-11(16)8-15(12)14(18)20-9-10-5-3-2-4-6-10/h2-6,11-12,16H,7-9H2,1H3/t11-,12+/m1/s1

Upstream product

• 62210-73-5 N-<<(benzyloxy)carbonyl>oxy>-5-norbornene-2,3-dicarboximide 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 124-41-4 sodium methylate 
• 13500-53-3 N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester 
• 186581-53-3 diazomethane 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 67-56-1 methanol 
• 501-53-1 benzyl chloroformate 
• 74-88-4 methyl iodide 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 16217-15-5 1-benzyloxycarbonyl-4-oxo-L-proline methyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 618-28-0 trans-4-hydroxy-D,L-proline 

Downstream Products

• 170159-62-3 (2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester 
• 367259-01-6 (2S,4R)-4-(3-Benzyloxy-1,1-dimethyl-propoxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 865436-06-2 2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 72956-58-2 C₂₀H₂₁NO₄ 
• 871810-83-2 (2S,4R)-benzyl 4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 865436-09-5 2S,4R-4-carboxymethoxy-2-(pyridin-2-ylaminomethyl)pyrrolidine-1-carboxylic acid benzyl ester 
• 700864-09-1 Cbo-(2S,4R)-Pro(4-OCO-NH-CH₂-CH₂-NH-Boc)-OMe 
• 948092-72-6 2S,4R-{4-carboxymethoxy-2-[(4-methoxypyridin-2-ylamino)-methyl]}pyrrolidine-1-carboxylic acid benzyl ester 
• 117811-78-6 methyl (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylate 
• 114358-14-4 O₁-benzyl O₂-methyl (2S,4R)-4-[tert-butyl(dimethyl)silyl]oxypyrrolidine-1,2-dicarboxylate 
• 117811-69-5 (2S,4R)-4-t-butyldimethylsilyloxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 1047403-22-4 C₂₁H₂₀N₂O₉ 
• 157187-10-5 C₂₀H₂₁NO₅ 

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