4766-33-0

Basic information

• Product Name: 5-BROMO-NAPHTHALEN-1-YLAMINE
• Synonyms: 5-BROMO-NAPHTHALEN-1-YLAMINE;5-bromonaphthalen-1-amine;1-NaphthalenaMine,5-broMo-;5-Bromo-1-naphthylamine
• CAS NO: 4766-33-0
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.08
• Mol File: 4766-33-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 66-68°C
• Boiling Point: 358 °C at 760 mmHg
• Flash Point: 170.3 °C
• Appearance: /
• Density: 1.5199 (rough estimate)
• Vapor Pressure: 2.63E-05mmHg at 25°C
• Refractive Index: 1.5870 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Very Slightly)
• PKA: 3.35±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-NAPHTHALEN-1-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-NAPHTHALEN-1-YLAMINE(4766-33-0)
• EPA Substance Registry System: 5-BROMO-NAPHTHALEN-1-YLAMINE(4766-33-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 4766-33-0(Hazardous Substances Data)

Usage

Uses

5-Bromonaphthalen-1-amine has inhibitory activity against KRAS G12D mutation.

InChI:InChI=1/C10H8BrN/c11-9-5-1-4-8-7(9)3-2-6-10(8)12/h1-6H,12H2

Upstream product

• 5328-76-7 1-bromo-5-nitronaphthalene 
• 86-57-7 1-Nitronaphthalene 
• 86-55-5 1-naphthalenecarboxylic acid 
• 7647-01-0 hydrogenchloride 
• 16726-67-3 5-bromo-1-naphthalenecarboxylic acid 

Downstream Products

• 52927-23-8 5-bromo-1-naphthol 
• 315-56-0 1-bromo-5-fluoronaphthalene 
• 77332-65-1 1-Bromo-5-chloronaphthalene 
• 77332-64-0 5-bromo-1-iodonaphthalene 
• 16650-52-5 5-chloro-naphthalene-1-carboxylic acid 
• 20816-78-8 5-Cyano-2-naphthol 
• 2375201-60-6 N-(3-(5-aminonaphthalen-1-yl)propyl)biotinamide 
• 76980-73-9 7-phenyl-1H-phenalen-1-one 

Relevant articles and documents

PONy Dyes: Direct Addition of P(III) Nucleophiles to Organic Fluorophores

Nucleophilic addition of phosphinic acid, phosphites, sodium dialkyl phosphites, phosphoramidites, phosphinites, and phosphonites to highly polarized or cationic fluorophores, followed by oxidation, results in new "PONy" dyes with auxochromic phosphinate, phosphonate, or phosphonamidate groups. The reaction was applied to a wide variety of coumarins, (thio)pyronins, and N-alkylacridinium and 5,6-dihydrobenzo[c]xanthen-12-ium salts as well as a meso-chlorinated BODIPY to provide compact dyes with red-shifted absorption and emission bands and Stokes shifts up to 8200 cm-1.

Synthesis of Positional Isomeric Phenylphenalenones

A series of isomeric phenylphenalenones in which the phenyl ring is located at all possible peripheral positions of the phenalenone nuclei was synthesized. The structural characteristics of the series, in which topological variation is permitted with minimal electronic disturbance, could, in principle, allow for easy pharmacophore recognition when the compounds are aligned in steroidomimetic conformations.

Direct cyanation of picolinamides using K4[Fe(CN)6] as the cyanide source

The efficient, simple, and environment-friendly route of direct cyanation of picolinamides has been developed with nontoxic K4[Fe(CN)6] as the cyanide source through Pdcatalyzed C-H bond activation. A series of N-(naphthalene-1- yl)picolinamide derivatives were successfully transformed to the corresponding cyanation products. The cyanation mechanism has also been speculated.