444805-28-1 Usage
Description
CMX 001 is a versatile compound with various applications across different industries, primarily due to its unique properties and characteristics.
Uses
Used in Antiviral Applications:
CMX 001 is used as an antiviral inhibitor for preventing the replication of BK polyomavirus in primary human urothelial cells. Its effectiveness in inhibiting viral replication makes it a valuable asset in the fight against viral infections.
Used in Cancer Treatment:
In the field of oncology, CMX 001 serves as a cytostatic and cytotoxic agent. It works by inhibiting the growth and proliferation of cancer cells, making it a potential candidate for cancer treatment. Its cytotoxic properties allow it to target and destroy cancer cells, while its cytostatic effects prevent them from dividing and spreading.
Used in Pharmaceutical Industry:
CMX 001 is used as an active pharmaceutical ingredient for the development of new drugs and therapies. Its diverse applications in antiviral and cancer treatment make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Drug Delivery Systems:
CMX 001 can also be utilized in the development of novel drug delivery systems. These systems aim to improve the bioavailability, delivery, and therapeutic outcomes of the compound by employing various organic and metallic nanoparticles as carriers for CMX 001.
Biological Activity
cmx001 is a broad spectrum antiviral agent [1].cmx001 has been reported to be active in vitro against a broad range of viruses from all five families of dsdna viruses infecting human with ec50 values of 0.02μm, 0.0004μm, 17μm , 0.045μm and 0.07μm for adenovirus, herpesvirus, papillomavirus, polyomavirus and orthopoxvirus, respectively. in addition, cmx001 has been revealed to arrest disease progression by inhibiting viral dna replication and thereby reducing viral burden. apart from these, initial studies has been demonstrated the efficacy of cmx001 for pre-exposure and post-exposure prophylaxis in mouse, rabbit, cynomolgus monkeys and human [1].
references
[1]lanier r1, trost l, tippin t, lampert b, robertson a, foster s, rose m, painter w, o'mahony r, almond m, painter g.development of cmx001 for the treatment of poxvirus infections. viruses. 2010 dec; 2(12):2740-2762.
Check Digit Verification of cas no
The CAS Registry Mumber 444805-28-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,4,8,0 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 444805-28:
(8*4)+(7*4)+(6*4)+(5*8)+(4*0)+(3*5)+(2*2)+(1*8)=151
151 % 10 = 1
So 444805-28-1 is a valid CAS Registry Number.
444805-28-1Relevant articles and documents
Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir
Kern, Earl R.,Hartline, Caroll,Harden, Emma,Keith, Kathy,Rodriguez, Natalie,Beadle, James R.,Hostetler, Karl Y.
, p. 991 - 995 (2002)
The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication i
Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
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Page/Page column 56, (2015/03/03)
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of ph
COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF POXVIRUS INFECTIONS
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Page/Page column 33, (2008/06/13)
The present application provides methods and compositions for combination therapy with antiviral compounds for the treatment of poxvirus infections, such as orthopox virus infections. In one embodiment, a method of treatment of a poxvirus infection is provided that comprises administering to a host in need thereof cidofovir, cyclic cidofovir, or a salt, ester, or prodrug thereof in combination or alternation with at least a second anti-poxvirus agent. The second anti-poxvirus agent is, for example, a biologic, such as a pegylated interferon.
METHODS FOR PREPARATION OF NUCLEOSIDE PHOSPHONATE ESTERS
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Page/Page column 31, (2010/02/14)
A process is provided for the preparation of lipophilic monoesters of formula (3) and their stereoisomers. The process includes the steps of esterification of a phosphonate with a lipophilic alcohol, then allowing the resultant product to react with a sui