443-87-8Relevant articles and documents
Method for synthesizing 3 - halogen -2 -alkyl phenol
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Paragraph 0035-0037, (2021/11/03)
The invention discloses a synthesis method of 3 -halo -2 - alkyl phenol, and belongs to the technical field of organic synthesis. At 2, 6 - dihaloalkylbenzene is used as starting material, nucleophilic substitution with dibenzyl alcohol in the presence of an inorganic base followed Pd / C hydrodebenzylation or Grignard exchange with magnesium metal in the presence of n-butylbromide/chloride followed by air/oxygen to give 3 - halo -2 - alkylphenols. The method has the advantages of high regioselectivity, good yield, simple operation process and the like, and the product purity can reach 99.5% or more.
MONOAMINE RE-UPTAKE INHIBITORS AND METHODS RELATING THERETO
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Page/Page column 29, (2010/11/25)
Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3, R4, R5, R6, m, n, W, X, Y, and Z are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts, esters and solvates thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting monoamine re-uptake in a subject in need thereof.