32345-59-8

Basic information

• Product Name: 2-CHLORO-MANDELIC ACID METHYL ESTER
• Synonyms: 2-CHLORO-MANDELIC ACID METHYL ESTER;(R)-Methyl 2-hydroxy-2-(2-chlorophenyl)acetate;Methyl (R)-o-chloromandelate;Methyl 2-(2-chlorophenyl)-(R)-2-hydroxyacetate;Methyl 2-Chloro-D-mandelate;Methyl 2-Chloro-D-mandelate;(R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate;methyl (R)-2-hydroxy-2-(2-chlorophenyl)acetate
• CAS NO: 32345-59-8
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.61896
• EINECS: 1592732-453-0
• Mol File: 32345-59-8.mol
• Article Data: 35

Chemical Properties

• Melting Point: 34 °C
• Boiling Point: 297.663°C at 760 mmHg
• Flash Point: 133.822°C
• Appearance: /
• Density: 1.316g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 11.82±0.20(Predicted)
• CAS DataBase Reference: 2-CHLORO-MANDELIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-MANDELIC ACID METHYL ESTER(32345-59-8)
• EPA Substance Registry System: 2-CHLORO-MANDELIC ACID METHYL ESTER(32345-59-8)

Safety Data

• Hazardous Substances Data: 32345-59-8(Hazardous Substances Data)

Usage

Uses

(R)-Methyl 2-Chloromandelate is an intermediate in the synthesis of Clopidogrel Carboxylic Acid [Methyl (R)-o-chloromandelate] Ester (C587320), which is an impurity of Clopidogrel (C587250), an antithrombotic agent.

InChI:InChI=1/C9H9ClO3/c1-13-9(12)8(11)6-4-2-3-5-7(6)10/h2-5,8,11H,1H3/t8-/m1/s1

Upstream product

• 34966-49-9 methyl 2-chlorobenzoylformate 
• 156276-21-0 rac-methyl 2-chloromandelate 
• 2743-38-6 O,O'-dibenzoyl-L-tartaric acid 
• 108-05-4 vinyl acetate 
• 89-98-5 2-chloro-benzaldehyde 
• 10421-85-9 2-chloromandelic acid 
• 13312-84-0 2-chloromandelonitrile 
• 264882-00-0 methyl 2-(2-chlorophenyl)-2-diazoacetate 
• 67-56-1 methanol 
• 10421-85-9 (R)-2-chloromandelic acid 

Downstream Products

• 1385019-32-8 1-(2-chlorophenyl)-(R)-1-(methoxymethoxy)-propyl-(S)-2-carbamate 
• 1314097-38-5 (S)-methyl 2-(2-pivaloyloxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate hydrochloride 
• 1444502-94-6 1-(2-chlorophenyl)-(R)-1-(t-butyldimethyl-siloxy)propane-2-on 
• 1444502-99-1 1-(2-chlorophenyl)-(R)-1-(t-butyldimethyl-siloxy)-(S)-2-propanol 
• 1444502-89-9 2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide 
• 113665-84-2 (S)-(+)-clopidogrel 
• 120202-66-6 (S)-(+)-clopidogrel bisulfate 
• 223123-46-4 methyl (R)-2-(2-chlorophenyl)-2-benzenesulfonyloxyacetate 
• 1360591-38-3 (S)-(2-chlorophenyl)(2-hydroxy-6,7-dihydro-4H-thiophene[3,2-c]pyridin-5-yl)acetic acid methyl ester 

Relevant articles and documents

Calcium(II)-mediated resolution of methyl o-chloromandelate with chiral O,O′-dibenzoyltartaric acid in preparative scale

We report here the coordination-mediated resolution of methyl o-chloromandelate, which is a key intermediate for clopidogrel, in preparative scale. The reaction of CaO, optically pure (2R, 3R)-O,O′-dibenzoyltartaric acid, and methyl o-chloromandelate in ethanol solution afforded a mixed-ligands calcium(II) complex that was further purified by stirring of the crystals in hot methanol. Methyl (R)-o-chloromandelate was obtained in good enantiomeric excess value (>99.5%) and yield (71%) by treatment of the complex with acid. At the same time, (2R, 3R)-O,O′-dibenzoyltartaric acid was recovered in 72% yield. In addition, methyl (S)-o-chloromandelate was obtained in good enantiomeric excess value (>99.5%) and yield (73%) by recovery from the mother liquor and resolution with the same procedure for methyl (R)-o-chloromandelate, except that (2S, 3S)-O,O′-dibenzoyltartaric acid was used as the resolving reagent.

Thienopyridine derivative, preparation method and application thereof

The invention relates to a thienopyridine derivative, a preparation method and application thereof. The thienopyridine derivative has a structure shown in the formula (I), wherein the group R1, R2, R3, R4, X1, X2 or X3 and m, n and w are as defined in the

A preparation method of clopidogrel hydrogen sulfate type II

The invention discloses a preparation method of clopidogrel hydrogen sulfate type II. The method comprises the following steps: (4) taking clopidogrel free alkali as a raw material, and reacting the clopidogrel free alkali with (1R)-(-)-10-camphorsulfonic acid in a reaction solvent to obtain clopidogrel camphorsulfonate, and hydrolyzing under an alkaline condition to obtain clopidogrel free alkali; and then preparing the clopidogrel hydrogen sulfate type II by taking the clopidogrel free alkali obtained in the step (4) as a raw material. The synthetic route is simple, the used solvent is cheap, the cost is saved, the generation of waste liquid is reduced, the recycling of the solvent is improved, and the prepared clopidogrel hydrogen sulfate type II has the characteristics of high purity,good quality, high yield, good stability, suitability for industrial mass production and the like.