26936-41-4

Basic information

• Product Name: POLYINOSINIC ACID (5') POTASSIUM SALT
• Synonyms: POLY[I] POTASSIUM SALT;POLYINOSINIC ACID (5') POTASSIUM SALT;POLYINOSINIC ACID POTASSIUM SALT;POLYINOSINIC ACID TRIPOTASSIUM SALT;POLY RL POTASSIUM SALT;polyinosinic acid (5') potassium;POLYINOSIC ACID, POTASSIUM SALT extrapure
• CAS NO: 26936-41-4
• Molecular Formula: C10H12KN4O8P
• Molecular Weight: 386.296341
• Product Categories: Biochemicals and Reagents;Biomaterials;Materials Science;Nucleosides;Nucleotides;Oligonucleotide Polymers and Copolymers;Oligonucleotides;Synthetic Oligonucleotides and Related Reagents
• Mol File: 26936-41-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: POLYINOSINIC ACID (5') POTASSIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: POLYINOSINIC ACID (5') POTASSIUM SALT(26936-41-4)
• EPA Substance Registry System: POLYINOSINIC ACID (5') POTASSIUM SALT(26936-41-4)

Safety Data

• WGK Germany: 3
• F: 3-10-21
• Hazardous Substances Data: 26936-41-4(Hazardous Substances Data)

Usage

Description

POLYINOSINIC ACID (5') POTASSIUM SALT, also known as Poly(I), is a homopolymer of inosine that plays a significant role in the field of immunology and cell signaling. It is commonly used in combination with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) ? Poly(C)). POLYINOSINIC ACID (5') POTASSIUM SALT is recognized by TLR3, a key receptor involved in the immune response against viral pathogens, making it a valuable tool for studying cell signaling and immune system activation.

Uses

Used in Immunology Research:
POLYINOSINIC ACID (5') POTASSIUM SALT is used as a model RNA for studying cell signaling at the level of TLR3. It helps researchers understand the mechanisms of immune response against viral pathogens and the role of TLR3 in this process.
Used in Drug Development:
In the pharmaceutical industry, POLYINOSINIC ACID (5') POTASSIUM SALT serves as a TRIF-dependent toll-like receptor-3 (TLR3) ligand. This property makes it a potential candidate for the development of new drugs targeting TLR3, which could have applications in treating viral infections and modulating the immune response.
Used in Diagnostics:
POLYINOSINIC ACID (5') POTASSIUM SALT can be employed in the development of diagnostic tools and assays to detect and measure the activity of TLR3. This can be useful in identifying individuals with compromised immune systems or those at risk for certain viral infections.
Used in Vaccine Development:
In the field of vaccine development, POLYINOSINIC ACID (5') POTASSIUM SALT may be utilized as an adjuvant to enhance the immune response to vaccines. By stimulating TLR3, it could potentially improve the effectiveness of vaccines against viral pathogens.